慢性非细菌性前列腺炎/慢性盆底疼痛综合征患者症状与白细胞计数的关系

The associations between severity of symptoms in men with Ⅲa, Ⅲb prostatitis and leukocyte counts

目的探讨慢性非细菌性前列腺炎/慢性盆底疼痛综合征患者(CAP/CPPS)症状与前列腺液、按摩后尿液、精液中白细胞计数间的关系。方法以前列腺炎症状评分(NIH-CPSl)评估CAP/CPPS患者症状情况,按四杯法留取尿液,对患者前列腺液、按摩后尿液、精液行白细胞计数,并对样本行细菌培养。将228例CAP/CPPS患者分型,对患者症状与实验室结果间行相关分析。结果CAP/CPPS患者中,依据EPS、VB3或精液中WBC数目而分型的Ⅲa型与Ⅲb患者间的CPSI中的疼痛、排尿不适、生活质量及总分无显著性差异(P值分别为0.97、0.75、0.08、0.55)。CAP/CPPS患者EPS、VB3或精液中WBC数目与CPSI中的疼痛、排尿不适、生活质量及总分无显著相关性(P值>0.05)。结论CAP/CPPS患者Ⅲa型与Ⅲb型间症状严重程度无显著性差异,白细胞计数与CAP/CPPS患者症状的严重程度无明显相关性,提示还有其他引起CPPS症状的因素存在。

Objective To investigate the associations between severity of symptoms in men with Chronic abacterial prostatitis/Chronic pelvic pain syndrome (CAP/CPPS) and leukocyte counts. Methods During January 2003 and February 2004, a total of 238 cases of patients had been diagnosed as CAP/CPPS. Severity of symptoms in men with CAP/CPPS was defined by the NIH Chronic Prostatitis Symptom Index including subscores (NIH-CPSI). Leukocytes were counted in expressed prostatic secretion (EPS) ,voided urine after prostatic massage(VB3) and semen. The patients were stratified into categories Ⅲa and Ⅲb based on WBC counts in these prostate specific specimens. Associations between severity of symptoms in men with chronic prostatitis and leukocyte counts were assessed using Spearman correlation and Kruskal-Wallis H nonparametric tests. Results None of the index measures were statisti- cally different between categories Ⅲa and Ⅲb(P>0.05). There was no significantly correlation in regard to severity of symptoms and leukocyte counts (P>0.05). Conclusion The severity of symptoms do not correlate with site specific leukocytes. Further discussion is needed to validate the distinction between category IlIA and IIIB in the NIH classification, and provide a supplementary tool to identify the cause of CPPS.