乙型肝炎患者外周血IL-18水平与肝功能指标的相关性分析及其意义

The correlation between liver function and serum interleukin-18 level in the peripheral blood in hepatitis B patients

目的 探讨乙型肝炎患者外周血白细胞介素-18(IL-18)水平与肝功能的相关性及其临床意义。方法 根据微粒子酶免疫法(MEIA)检测乙型肝炎病毒(HBV)感染血清学标志的结果分为:A组,HBsAg、HBeAg、HBcAb阳性;B组,HBsAg、HBeAb、HBcAb阳性;对照组,单独HBsAb阳性。用酶联免疫吸附试验(ELISA)测血清IL-18水平,常规方法测定血清丙氨酸转氨酶(ALT)、天门冬氨酸转氨酶(AST)、总胆红素(TBil)、γ- 谷氨酰转移酶(GGT)浓度。结果 乙型肝炎患者IL-18水平明显高于对照组(P<0. 01),以A组水平最高,IL-18与ALT、TBil呈正相关,与GGT无相关性。结论 IL-18可能参与了病毒性肝炎肝脏的炎性损伤过程。

Objective To study the correlation between liver function and serum interleukin-18(IL-18) level in patients with hepatitis B and its clinical significance. Methods Patients were divided into 3 groups according to HBV markers determined by microparticle enzyme immunoassay(MEIA): HBsAg+, HBeAg+, HBcAb+(group A); HBsAg+, HBeAb+, HBcAb+(group B); individuals with HBsAb+ (control group). Serum IL-18 level was determined by ELISA and ALT, AST, TBil, GGT were measured. Results The levels of serum IL-18 of patients in group A and B were significantly higher than that in controls group(P<0.01). The level of IL-18 in group A was the highest among three groups. Moreover, there was a close positive correlation between IL-18 and ALT, TBil. Conclusions IL-18 may participate in liver damages of hepatitis B patients.