高脂血症与血浆凝血因子Ⅶ活性的相关性研究

The correlation study between hyperlipidemia and the activity of coagulation factor Ⅶ

目的:探讨高脂血症与血浆凝血因子Ⅶ活性升高的相关性。方法:比较高脂血症病人(100例)和正常血脂对照组(109例)间血浆凝血因子活性的差别;用直线相关和多元逐步回归分析血浆Ⅶ活性和血脂等之间的线性相关关系;Logistic回归分析血浆Ⅶ活性对高脂血症发病的影响程度。结果:高脂血症组凝血因子Ⅶ(FⅦ)活性(156.11%±37.61%)高于正常对照组(132.50%±24.01%),(P<0.001);FⅦ活性与年龄、TC、TG、LDL-C、FIB、GLU呈正相关(P<0.01)、与TC、TG、HDL-C、FIB呈线性关系;Logistic回归分析高脂血症与BMI、FⅦ有统计学意义,P<0.01。结论:高脂血症病人血浆凝血因子Ⅶ活性升高,呈显著正相关。FⅦ活性的增高对高脂血症病人的动脉血栓形成发病可能有直接的关系。

Objective:To investigate the correlation between the hyperlipidemia and the activity of coagulation factor Ⅶ.Methods:The activity of factor Ⅶ in normal control group was compared with that in the hyperlipaemic group, the correlation between blood lipids and the activity of factor Ⅶ and its influence on hyperlipidemia was also analyzed.Results:The activity of factor Ⅶ in the hyperlipaemic group was significantly higher than that in the normal control group (156.11%±37.61% vs 132.50%±24.01%, P<0.001), positive correlation was found between the activity of factor Ⅶ and age, TC, TG, LDL-C, FIB, GLU (P<0.01).Conclusion:There was significant positive correlation between blood lipids and the activity of factor Ⅶ, the increase of the activity of factor Ⅶ may induce the rate of recurrence of arterial occlusion.