摘要
背景:目前国内外对痴呆症治疗方法和药物较多。杏丁和吡拉西坦(脑复康)是一种循环障碍改善剂和神经细胞保护剂,可减慢脑组织功能减退,对认知功能障碍具有改善作用。目的:观察杏丁与吡拉西坦联合应用治疗血管性痴呆对认知功能的改善作用。设计:以患者为观察对象的病例对照研究。单位:河南大学第一附属医院神经科。对象:2000-10/2002-03河南大学第一附属医院神经内科住院血管性痴呆患者91例,随机分为治疗组48例和对照组43例。干预:治疗组以杏丁注射液20mL加吡拉西坦8g分别加入50g/L葡萄糖注射液250mL中静脉滴注,1次/d,14d为1个疗程;对照组以吡拉西坦8g加入50g/L葡萄糖注射液250mL静脉滴注,1次/d,14d为1个疗程。两组其他治疗药物无差别。两组于治疗结束后1个月以复查简明智能状态检查量表,长谷川痴呆修改量表评估对认知功能的改善,以神经功能缺损评分分析神经功能症状的改善。主要观察指标:①两组患者简明智能状态检查量表,长谷川痴呆修改量表及神经功能缺损评分。②疗效分析。结果:91例患者均进入结果分析。两组治疗前简明智能状态检查量表和长谷川痴呆修改量表评分相比差异均无显著性意义,治疗组治疗后简明智能状态检查量表和长谷川痴呆修改量表评分[(23.26±5.12)分和(2.78±3.46)分]与对照组[(19.
BACKGROUND:At present,there are many drugs and therapeutic methods for dementi a at home and abroad.Both xingding and piracetam are the kind of improver for ci rculatory obstruction and protector for nerve cells and can slow down the functi onal decline of brain tissue and provide improvement for cognitive deficit. OBJECTIVE:To observe the improvement of allied application of xingding and pir acetam on cognitive function in treatment of vascular dementia. DESIGNS:Case controlled study based on patients. SETTING:Neurological Department in Affiliated Hospital of Henan University. PARTICIPANTS:Totally 91 cases of vascular dementia hospitalized in Neurologica l Department of First Affiliated Hospital of Henan University from October 2000 to March 2002,which were randomized into treatment group of 48 cases and the con trol of 43 cases. INTERVENTIONS:In treatment group,xingding injection of 20 mL and piracetam of 8 g were administrated and 50 g/L glucose injection 250 mL was added respectivel y for intravenous injection,once daily and 14 days made one session.In the contr ol,piracetam of 8 g was prescribed with 50 g/L glucose injection 250 mL added fo r intravenous injection,once daily and 14 days made one session. There was no an y difference in other medication treatment.One month later after treatment of tw o groups,he patients were re examined with mini mental state examination(MMSE) and Hasegawa dementia scale(HDS) was used to assess the cogitative improvement and neurological defect scale(NDF) was used to analysis the improvement of neuro logical functional symptoms. MAIN OUTCOME MEASURES:①Scores of MMSE, HDS and NDF in two groups.②Analysis o n therapeutic effects. RESULTS:Totally 91 cases entered the analysis on the results.There was no sign ificant difference in MMSE and HDS before treatment in two groups.In treatment g roup,after treatment,MMSE and HDS scores were(23.26±5.12) and(2.78±3.46) respe ctively,indicating significant difference(t=4.79, 15.44,P< 0.01) compared with t he control(19.14±3.21) and(15.21±2.29).NDF score was 13.68±7.83 after treatme nt and the significant difference was presented compared with the control(17.33 ±8.81).The total effective rate(total remarkable rate+progression) was 92%in the treatment group and was 56%in the control.By the comparison between two gro ups, the difference was significant(χ2 =15.48,P< 0.01). CONCLUSION:After treatment, MMSE score in treatment group was higher than that in the control and HDS score was lower than that in the control,explaining that xingding allied piracetam significantly improves cogitative function in the tre atment of vascular dementia.
出处
《中国临床康复》
CSCD
北大核心
2005年第16期231-233,共3页
Chinese Journal of Clinical Rehabilitation