期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

白细胞介素-4的研究进展 被引量：29

Reaserch progress of interleukin-4
下载PDF
导出
摘要 目的综述白细胞介素-4(interleukin-4,1L-4)的研究进展。方法对近年来的文献进行整理归纳。结果IL-4在介导炎症以及过敏性疾病的发生发展中起着极其重要的作用,因此寻找高效IL-4抑制剂或拮抗剂是此类疾病药物研究的有效途径;同时IL-4及其结构修饰物在肿瘤、自身免疫性疾病等方面研究中显示出一定的效果。结论IL-4在免疫网络调节中作用复杂,在不同的疾病治疗中应进一步明确其作用机制,进行合理药物设计、改造或采用更有效的治疗方案以提高治疗效果、减小不良反应。
作者 胡洪慧 王凤山 凌沛学
机构地区 山东大学药学院生化与生物技术药物研究所 山东省生物药物研究院
出处 《中国药学杂志》 CAS CSCD 北大核心 2005年第10期721-725,共5页 Chinese Pharmaceutical Journal
关键词 白细胞介素-4 白细胞介素-4受体 炎症 过敏性疾病 肿瘤 自身免疫性疾病 基因治疗
分类号 Q813 [生物学—生物工程]
  • 相关文献

参考文献40

  • 1Eisenmesser EZ,Horita DA,Mtieri AS,et al.Solution structure of interleukin-13 and insights into receptor engagement[J].J Mol Biol, 2001,310(1):231.
  • 2Moy FJ, Diblasio E,Wilhelm J,et al.Solution structure of human interleukin-13 and implication for receptor binding[J].J Mol Biol, 2001,310(1):219.
  • 3Zhang JL,Simeonowa I,Wang Y,et al.The high-affmity interaction of human IL-4 and the receptor a chain is constituted by two independent binding clusters[J].J Mol Biol,2002,315(3):399.
  • 4Rudge EU,Cutler AJ,Pritchard NR,et al.Interleukin-4 reduces expression of inhibitory receptors on B cells and abolishes CD22 and Fc garrmaa RII-mediated B cell suppression[J].J Exp Med, 2002,195(8):1079.
  • 5Sudowe S,Arps V,Vogel T,et al.The role of interleukin-4 in the regulation of sequential isotype switch from inwnunoglobtdin G1 to immunoglobtdin E antibody production[J].Scand J lmmonol, 2000,51(5):461.
  • 6Kotowicz K,Dixon GL,Klein NJ,et al.Biological function of CD40 on human endothelial cells:costimtdation with CD40 ligand and interleukin-4 selectively induces expression of vasctdar cell adhesion molecule-1 and P-selectin restthing in preferential adhesion of lymphocytes[J],Immunology,2000,100(4):441.
  • 7Jinquan T,Quan S,Jacobi HH,et al.CXC chemokine receptor 4 expression and stromal cell-derived factor-lalpha-induced chemotaxis in CD4^+T lymphocytes are regulated by interkeukin-4 and interleukin-10[J], Immunology,2000,99(3):402.
  • 8刘东,朱利泉.信号转导和转录激活因子STAT6的结构与功能[J].生命的化学,2001,21(3):252-254. 被引量：3
  • 9So EY,Kim SH,Park HH,et al.Corticosteroid inhibits IL-4 signaling through down-regulation of IL-4 receptor and STAT6 activity[J].FEBS Lett,2002,518(1-3):53.
  • 10张勇,李元.可溶性白细胞介素4受体的研究进展[J].国外医学（药学分册）,2003,30(6):344-348. 被引量：3

二级参考文献23

  • 1Chen C H，Mol Cell Biol，1998年，18卷，6期，3395页
  • 2Chen H, Paul WE. Cultured NK1.1+ CD4+ Tcells produce large amounts of IL-4 and IFN-γ upon activation by anti-CD3 or CD1[J]. JImmunol, 1997, 159(5):2240-2249.
  • 3Seder RA, Paul WE, Davis MM, et al. The presence of interleukin-4 during in vitro priming determines the lymphokine-producing potential of CD4 + T cells from T cell receptortransgenic mice[J].J Exp Med, 1992, 176(4):1091 - 1098.
  • 4Gascan H, Gauchat JF, Roncarolo MG, et al. Human B cell clones can be induced to proliferate and to swith to IgE and IgG4 synthesis by interleukin 4 and a signal provided by activated CD4+ T cell clones[J]. J Exp Med, 1991, 173(3):747-750.
  • 5Sager N, Feldmann A, Schilling G, et al. House dust mite-specific T cells in the skin of subjects with atopic dermatitis: frequency and lymphokine profile in the allergen patchtest[J]. J Allergy Clin Immunol, 1992, 89(4):801 - 810.
  • 6Pawankar R, Okuda M, Yssel H, et al. Nasal mast cells in perennial allergic rhinitis exhibit increased expression of the Fc epsilonRI, CD40L, IL-4 and IL-13 ,and can induce IgE synthesis in B cells[J]. J Clin Irwest, 1997, 99(7):1492- 1499.
  • 7Duschl A, Sebald W. Trammembrane and intracellular signalling by interleukin-4: receptor dimerization and beyond[J]. Eur Cytokine Netw , 1996, 7(1):37-49.
  • 8Prithard MA, Baker E, Whitmore SA, et al. The interleukin-4 receptor gene(IL-4R)maps to 16p11.2 - 16p12.1in human and to the distal region of mouse ehromosome 7[J]. Genetics, 1991, 10(3) :801 - 806.
  • 9Livnah O, Stura EA, Johnson DL, et al. Functional mimicry of a protein bormone by a peptide agonist: the EPO receptor complex at 2.8 A [J]. Science, 1996, 273(5274) :464 - 471.
  • 10Mitsuyasu H, Izuhara K, Mao XQ, et al. Ile50Val variant of IL-4Rα upregulates IgE synthesis and associates with atopic asthma[J]. Nat Genet, 1998, 19(2) :119 - 120.

共引文献4

同被引文献241

引证文献29

二级引证文献139

中国药学杂志
2005年 第10期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部