严重急性呼吸综合征304例临床治疗方案探索性分析

Analyzing the clinical therapeutic schemes on 304 severe acute respiratory syndrome cases

目的探讨抗生素、抗病毒药、免疫调节剂及营养支持的联合使用在严重急性呼吸综合征(SARS)患者治疗中的作用。方法分析太原市定点医院304例住院确诊SARS病历,探讨四种不同治疗方案对SARS患者的临床疗效。结果接受四种方案治疗后患者的住院时间差异有统计学意义(F=11.107,P<0.01),方案D较方案A、B、C的平均住院时间短;四种方案体温恢复正常的时间差异有统计学意义(F=4.794,P=0.003),方案A比其他三种方案的体温恢复正常的时间长;接受四种方案治疗的SARS患者治疗结果差异有统计学意义(确切概率P=0.001),方案A比其他三种方案的病死率高。结论抗生素、抗病毒药联合免疫调节剂或营养支持的疗效优于单独使用抗生素和抗病毒药。

Objective To evaluate the therapeutic effect of several remedies, including antibiotic, antiviral, immune modulator and trophotherapy, on the patients with severe acute respiratory syndrome (SARS). Methods Clinic effectiveness of different schemes on SARS patients was evaluated, 304 SARS cases were analyzed. Results Firstly the difference of patients′ hospital stays has statistical meaning(F=11.707, P<0.01), patients with scheme D stayed in hospital more shortly than those with other schemes. Secondly, the difference of time for patients′ temperature to return normal has a point in statistics(F=4.794, P=0.003), patients using scheme A needed more cure time before their temperature returned to normal. Finally, there was a significant statistical difference of curative effects among the four schemes(real probability P=0.001), case fatality ratio in patients with scheme A was higher than that with other schemes . Conclusion Therapeutic effect of combined scheme of antibiotic, antiviral and immune modulator or trophtherapy is better than that of using antibiotic and antiviral alone.