摘要
目的:比较苍耳子不同方法提取物灌胃给予动物后,产生的毒性反应。方法:急性毒性实验采用小鼠灌胃给药测定其半数致死量(LD50)和最大耐受量(MTD),长期毒性实验采用大鼠灌胃给药1个月,检测不同时期的血常规,肝、肾功能生化指标及病理组织学检查。结果:苍耳子水提物小鼠灌胃给药的LD50及其95%可信限为201.14(181.01～223.51)g生药/kg,苍耳子醇提物小鼠灌胃给药的MTD大于2400.0g生药/kg。苍耳子不同提取物大鼠灌胃给药1个月后的各项指标检测未见异常。结论:苍耳子水提物的急性毒性明显大于醇提物。两者长期毒性试验结果无差别。
Objective:To compare toxicity response of different extractions from Fructus Xanthii.Methods:In acute toxicity experiment LD_(50) and MTD in mice were determined. In chronic toxicity experiment, blood regular indexes of liver, kidney in different period were also determined.Results:1)LD_(50)(P<0.05)201.14(181.01～223.51)g material drug/kg, from water extraction.2)MTD is 2 400.0 g material/kg from alcohol extraction. Verities standards of different extractions are positive results.Conclusion:The toxicity of the water extraction is stronger than the toxicity of alcohol extraction.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2005年第6期484-487,共4页
Lishizhen Medicine and Materia Medica Research
关键词
苍耳子
提取物
毒性
Fructus Xanthii
Extractions
Toxicity
