吗啡、食物诱导的条件性位置偏爱获得与保持的比较

Comparison between Acquisition and Retention of Morphine and Food-Induced Conditioned Place Preference

应用条件性位置偏爱模型研究了大鼠吗啡与食物条件性位置偏爱(CPP)获得与保持的差异,结果发现,经过6轮训练后吗啡与食物都形成相同程度的条件性位置偏爱;但5次熄灭测试后吗啡的条件性位置偏爱程度没有明显的消退,而食物的条件性位置偏爱明显消退.表明经过充分训练后吗啡与食物奖赏记忆的获得没有显著差异,但吗啡奖赏记忆保持时间更长.

To confirm the hypothesis that persistence of addiction is caused by reward-related memory of addictive drugs. 24 rats, in food restriction, were trained in biased conditioned place preference procedure. Both morphine and food established conditioned place preference at the same level after 6 sessions training. Food-induced CPP was extinct, while morphine-induced CPP was preserved after 4 retests. It is suggested acquisition of conditioned place preference produced by morphine and food is similar, however, morphine CPP is maintained longer. The inveterate reward-related memory induced by addictive drugs is a major factor for the persistence of addiction.