一氧化碳中毒患者血浆NO含量与迟发性脑病的关系

The Relationship between Plasma Nitric Oxide (PNO) and Delayed Brain Disease Following Acute Carbon Monoxide Poisoning

目的探讨急性一氧化碳中毒患者血浆一氧化氮(NO)含量与迟发性脑病的关系。方法将62例急性CO中毒患者分为两组:迟发性脑病组(A组)29例和未发生迟发性脑病组(B组)33例。采用检测NO的中间代谢产物亚硝酸盐来反映A、B两组患者连续血浆的NO水平,并与正常对照组进行比较。结果A、B两组中毒后第1天血浆NO含量均明显低于正常对照组(P<0.01,P<0.05),A、B组第5天血浆NO含量均明显低于正常对照组(P<0.05),A组第10天血浆NO含量明显低于B组、正常对照组(P<0.05)。结论动态观察急性一氧化碳中毒后病人血浆NO变化有助于预测迟发性脑病的发生。

Objective To explore the relationship between plasma Nitric Oxide (PNO) and Delayed Brain Disease following acute carbon monoxide poisoning.Methods PNO levels of acute COP patients were measured constantly by detecting nitris of NO middle objects.Results The PNO levels of patients with acute COP were obviously lower than that of control group.The PNO levels of patients with delayed brain disease following acute COP were even lower than that of acute COP patients without delayed brain disease and that of control group on the fifth day and tenth day.Conclusion It is helpful to direct and forecast the occurrence and treatment of delayed brain disease following acute COP by measuring constantly the PNO levels of patients.