原发性肾病综合征患儿血清白介素-8水平的变化及意义

Clinical Significance of Serum Interleukin 8 in Children with Primary Nephritic Syndrome

目的探讨原发性肾病综合征患儿血清白介素-8(IL-8)水平的变化及其在肾病综合征发病中的作用和意义。方法采用ELISA法检测急性期18例和缓解期18例患儿及30例正常健康儿童血清IL-8的水平,同时检测血清白蛋白,作统计分析。结果原发性肾病综合征患儿急性期组血清IL-8水平显著高于正常对照组及缓解期组(P<0.05);缓解期组血清IL-8水平高于正常对照组,但无显著性差异(P>0.05)。急性期组和缓解期组血清白蛋白显著低于正常对照组(P<0.05);急性期组血清白蛋白显著低于缓解期组(P<0.05)。36例肾病综合征患儿急性期血清IL-8水平与血清白蛋白水平呈负相关(r=-0.52,P<0.05)。结论IL-8在血清中的含量与肾小球病理损伤密切相关,因此对肾病综合征患儿IL-8水平进行监测对判断肾病综合征损伤、预后判断等可能具有一定的临床意义。

Objective To explore the change of serum Interleukin 8 level in children with primary nephritic syndrome(PNS).Methods The levels of serum Interleukin 8 and albumin A were determined in children with primary nephritic syndrome in acute and stable stage respectively by ELISA.Results The level of serum Interleukin 8 in children with PNS in acute stage was obviously higher than those in stable stage and control group.There was no significant difference of serum Interleukin 8 levels between the PNS group in stable stage and the control group.The level of serum albumin A in PNS group was distinctly lower than that in the control group as well as that in PNS group in acute stage was lower than that in stable stage.There was a negative correlation between the level of Interleukin 8 and the level of albumin A in children with PNS.Conclusion It is concluded that the level of serum Interleukin 8 in children with PNS is correlate with the injury in renal corpuscle.The measurement of Interleukin 8 may be used as an index to evaluate the degree of renal damnify and the prognosis in children with PNS.