妊高征及高龄孕妇早期肾损伤实验室指标测定的临床意义

The Clinical Significance of Lab Tests of Renal Failure in EPH and Elder Pregnants

目的探讨妊娠高血压综合征及高龄孕妇早期肾损伤实验室指标测定的临床意义。方法对30例正常人组、65例正常孕妇组、20例大龄孕妇组和30例妊娠高血压综合征组检测尿NAG、Cr、24h尿蛋白、PRO及血BUN、Cr。NAG、Cr速率法,尿蛋白终点法。比较正常人、正常孕妇不同孕期、大龄孕妇及妊娠高血压综合征不同程度时各指标变化。结果正常孕妇组(妊娠中期组、晚期组)和妊娠高血压综合征各组尿NAG浓度均明显高于正常人组和妊娠早期组(P<0.05,P<0.01),正常孕妇组、大龄孕妇组和妊娠高血压综合征组血清Ccr浓度均明显低于正常人组(P<0.01),正常孕妇早、中期组24h尿蛋白和尿PRO与正常人组比较无显著性差异(P>0.05),正常孕妇晚期组有显著性差异(P<0.05),妊娠高血压综合征各组24h尿蛋白和尿PRO均明显高于正常人组和正常孕妇各组(P均<0.01)。结论NAG和PRO联合测定,简便快速,且能敏感反映高龄孕妇早期肾损伤。

Objective To investigate the changes of N-acetyl-β-D-glucosaminidase(NAG)、Ccr、urinary protein,ect, in pregnancy and find the more sensitive tests to detect minor renal damage in early stage.Methods NAG、Cr with kinetic and urinary protein with end were detected in normal person、normal and elder pregnants in various stage and edema proteinuria hypertension(EPH)in various degree.Results The NAG concentrations of normal pregnants and EPH were markedly elevated than that in normal persons(P<0.05,P<0.01).While the Ccr concentrations in elder pregnants and EPH were decreased than that in normal persons and normal pregnants(P<0.05,P<0.01).The changes of 24 h urinary protein and urinary PRO did not show any difference in early、middle pregnancy and normal person,but in the other stages it showed an obvious difference or very obvious difference between each other Conclusion Detection of both NAG and urinary PRO can sensitively show minor renal damage in EPH and elder pregnants and the method is simple and rapid.