基因转录另路剪接及其在临床药理学的研究进展

Alternative splicing of gene transcription and its progress in clinical pharmacology

另路剪接(alternativesplicing)是“有限”基因产生极其丰富蛋白最主要的原因,对维持机体正常功能有重要意义。因此根据相关基因的剪接变异表达特点,利用各种手段调节剪接变异产物的表达以恢复机体正常功能,提高药物治疗效果,减少药物毒副作用是药物基因组学重要的研究领域之一。

Alternative splicing is strictly affected by special cell or tissue and the stage of development so that it plays a vital role in development, cell or tissue differentiation and their function, accordingly, abnormal splicing will cause the functional disorder of body, and heritable diseases. Currently, the investigation on regulation of alternative splicing and its mechanism, function of its products and how to apply it into clinical practices is one of the extremely important area of pharmacogenomics