肥大细胞在轴突末梢间起中介作用的形态学证据

A MORPHOLOGICAL EVIDENCE OF THE MAST CELL ACTING AS A RELAY BETWEEN THE ADJACENT NERVE TERMINALS IN THE HUMAN SKIN

用光镜免疫细胞化学技术在人皮肤真皮深层发现两根P 物质样轴突末梢与同一肥大细胞形成突触样联接.其轴突末梢形成的终扣分别为3.0×1.5μ和2.4×1.0μ左右。在终扣内有线粒体和直径约200nm 大小的囊泡。从而为Lembeck提出的轴突反应模式和张保真提出的轴突反射、接力联动模型提供了迄今最直接的形态学证据,证明了神经-肥大细胞联接的双向性传导及肥大细胞在相邻两轴突末梢间信息传递过程中的中介作用。

Using light microscopic immunocytochemical technique,the synapse-like structures formed by two substance P immunoreactive nerve terminals which come from differental direction with one mast cell were foundin the depths of the reticular layer of human skin.Theboutons were 3×1.2 micron and 2.4×1 micronrespectively.There were mitochondrias and vesicalswhose diameter was 200 nm approximatly in theboutons.This discover was a direct morphological evi-dence for the axon response theory advanced byLembeck and the axon reflex relay action hypothesis ad-vanced by Zhang,also provided a evidence for thetwo-way conduction of this model,and confirmed thatthe mast cell can act as a relay between the adjacentsubstance P-like nerve terminals in the human skin.