期刊文献+

冠状动脉易损斑块的药物干预

下载PDF
导出
摘要 急性冠脉综合征(ACS)是心血管病患者发生心脏事件的主要原因,粥样斑块发生破裂,并且在此基础上继发血栓形成是ACS的主要病理基础。目前将那些濒临破裂,进而发生血栓和(或)迅速进展的粥样斑块称为易损斑块(VP)。及时识别或检出冠脉易损斑块并给予积极有效的干预,对于临床有效预防ACS具有十分重要的意义。现就近年有关易损斑块的药物干预研究综述如下:
作者 陈园频
出处 《中国医学文摘(内科学)》 2005年第3期351-354,共4页 China Medical Abstracts
  • 相关文献

参考文献12

二级参考文献121

  • 1[1]Conti CR. Updated pathophysiologic concepts in unstable coronary artery disease [J]. Am Heart J,2001 ,141(2 suppl) :S12-S14.JJ, Yang H, et al. Monoclonal T-cell proliferation and zzo G, Goronzy
  • 2[2]Liuplaque instability in acute coronary syndromes[J]. Circulation, 2000, 101:2883-2888.
  • 3[3]Stulc T, Ceska R. Cholesterol lowering and the vessel wall: new insights and future perspectives[J]. Physiol Res,2001,50:461-471
  • 4[4]Wilson JM, Chowdhury NR, Grossman M, et al. Temporary amelioration of hyperlipidemia in low density lipoprotein receptor-deficient rabbita transplanted with genetically modified hepatocytes[J]. Proc Natl Acad Sci lISA,1990,87: 8437-8441.
  • 5[5]Wilson JM. Clinical protocol. Ex vivo gene therapy of familial hypercholesterolemia[J]. Hum Gene Ther, 1992,3:179-222.
  • 6[6]Kohayashi K, Oka K. Reversal of hypercholesterolemia in low denaity lipoprotein receptor knockout mice by adenovirus-mediated gene transfer of the very low density lipoprotein receptor[J]. J Biol Chem ,1996,271:6852-6860.
  • 7[7]Benoit P, Emmanuel F, Caillaud JM, et a1. Somatic gene transfer of human ApoA-1 inhibits atherosclerosis progression in mouse models[J]. Circulation, 1999,99:105-110.
  • 8[8]Hughes SD, Verstuyft J, Rubin EM, et al. HDL deficiency in genetically engineered mice requires elevated LDL to accelerate atherogenesis[J]. Arterioscler Thromb Vasc Biol, 1997,17 : 1725-1729.
  • 9[9]George SJ. Therapeutic potential of matrix metalloproteinase inhibitors in atherosclerosis[J]. Expert Opin Investig Drugs, 2000, 9:993-1007.
  • 10[10]Ricote M, Li A, Wilson T, et al. The peroxisome proliferater-activated receptor- is a negative regulator of macrophage activation [J]. Nature,1998,391 : 79-82.

共引文献396

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部