青钱柳对小鼠胃排空的抑制作用

Inhibition of Gastric Emptying in Mice with Cyclocarya paliurus (Batal.) Iljinsk

目的:观察青钱柳提取物对小鼠胃排空的影响。方法:小鼠灌胃给予酚红溶液,30分钟后处死,以比色法测定胃中酚红残留量,计算胃排空百分率。结果:青钱柳的正丁醇部位、氯仿部位、石油醚部位及水相均有抑制小鼠胃排空作用,其效果明显比阳性对照大黄更强。结论:青钱柳的各部位提取物均能抑制小鼠胃排空。

Aim: To observe the effects of extracts of the leaves of Cyclocarya paliurus (Batal.) Iljinsk on gastric emptying (GE) in mice. Method: Mice were orally administered phenol red solution. After 30 min, the residue amount of phenol red in stomach was determined by means of colorimetry. The GE percentage was calculated subsequently.Result: The dry leaf of Cyclocarya paliurus (Batal.) Iljinsk was extracted by petroleum ether, n-butanol, chloroform and water respectively. All the above four fractions displayed significant inhibited GE at a dose of 150 mg/kg. The water extracts of Rehi was co-assessed as the positive control. Conclusion:The extracts of the leaves of Cyclocarya paliurus (Batal.) Iljinsk clearly inhibits GE in mice.