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DNA疫苗免疫原性的研究策略 被引量：2

Research strategy for immunogenicity of DNA vaccine
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摘要 DNA疫苗既能诱导体液免疫又能诱导细胞免疫,是近年来疫苗研究的热点领域,被称为疫苗史上的第三次革命,但DNA疫苗诱导特异性免疫应答的水平不高,限制了它的广泛应用。本文对提高DNA疫苗免疫原性的几种策略进行综述。 As the third revolution in vaccine field, DNA vaccine can generate humoral and cellular immunity. But the level of specifie cellular immunity elicited by DNA vaccine is not enough high, which limit the application of DNA vaccine in extensive fields. This review gives an overview of strategies to enhance immunogenicity of DNA vaccine
作者 摆茹 王希良 周亚
机构地区 军事医学科学院微生物流行病学研究所
出处 《免疫学杂志》 CAS CSCD 北大核心 2005年第B06期28-31,共4页 Immunological Journal
关键词 DNA疫苗 免疫原性 载体 佐剂 ON A vaccine Immunogenicity Vector Adjuvant
分类号 R392.1 [医药卫生—免疫学]
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参考文献23

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  • 2Anjeanette R, Yang ZY, Kong WP, et al. A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice [J]. Nature, 2004,428(6 928) :561 - 564.
  • 3Alexander J, del Guercio MF, Qiao L, et al. Liner PADRE T helper eoitope ang carbo hydrate B cell epitope conjugates induce specific high titer IgG antibody responses [J]. Immunology, 2000,164(3) :1 625 - 1 633.
  • 4Markwin PV, Sanne W, Gretchen L, et al. Defined flanking spacers and enhanced proteolysis is essential for eradication of established rumors by an epitope string DNA vaccine[J]. Immunologv, 2001,166:5 366- 5 373.
  • 5赵平,姜春鹏,赵兰娟,温新宇,戚中田.HBV包膜-核心蛋白融合基因DNA疫苗诱导小鼠持久的细胞免疫应答[J].生物化学与生物物理进展,2002,29(4):576-582. 被引量：13
  • 6Heinen PP, Rijsewijk FA, de Boer Luijtze EA, et al. Vaccination of pigs with a DNA construct expressing an influenza virus M2-nucleoprotein fusion protein exacerbates disease after challenge within fluenza A virus [ J ]. General Virol, 2002,83:1 851 - 1 859.
  • 7Jathoul AP, Holley JL, Garmory HS, et al. Efficacy of DNA vaccines expressing the type F botulinum toxin Hc fragment using different promoters [J]. Vaccine, 2004, 22:3 942 -3946.
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同被引文献40

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二级引证文献11

免疫学杂志
2005年 第B06期

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