摘要
随着分子生物学技术的发展,分子文库技术被越来越多地应用于感染性疾病血清学诊断试剂的研制。特别是当病原体不易人工培养或难于制备纯化抗原时,这种技术较传统诊断抗原筛选方法具有明显的优势。本文综述了基因文库、噬菌体展示肽库及噬菌体抗体库技术在血清学诊断试剂研制中的应用及其各自的优点。
With the development of molecular biology, more and more kinds of molecular libraries have been applied in the research of serodiagnostic reagents for infectious diseases. The molecular library technology has special values compared with conventional techniques for serodiagnostic screening of antigens, especially when the pathogens are difficult to culture artificially or the specific antigen purification is hard. In the present paper the application of DNA library, phage display random peptide library, phage antibody library, etc. in the research of serodiagnostic reagents and their special values were reviewed.
出处
《中国比较医学杂志》
CAS
2005年第3期179-181,共3页
Chinese Journal of Comparative Medicine
关键词
分子文库
血清学试验
传染病
Molecular library
Serodiagnostic technology
Infectious diseases
