种植体磷酸钙溶胶表涂与早期骨整合研究

The osteoconduction of calcium phosphate sol-gel coating for early osseointegration on implants

目的探讨磷酸钙(CaP)溶胶涂层能否传导并增强多孔型钛合金(Ti6Al4V)种植体表层的早期骨整合(即骨性愈合)。方法将制备有极薄的CaP溶胶表面涂层的多孔型钛合金种植体作为实验组,将未经CaP涂层的种植体作为对照组,分别植入16只兔的胫骨中。种植区愈合2周后,取含种植体的骨组织标本,利用反向扫描电镜摄像技术和Bioquant图像分析系统进行形态观测研究。结果在多孔型钛合金种植体表面,CaP涂层组所测量出的绝对骨接触长度(ACL:1.18mm)、接触长度分数比(CLF:40.4%)、骨生长直线距离(SLBG:1.19mm)各数据均高于对照组种植体(分别为0.74mm,27.0%,1.04mm),两组差异有统计学意义(P<0.01)。结论多孔型种植体CaP溶胶涂层能有效传导并增强骨组织长入,形成骨与种植体界面的广泛骨整合。

Objective To determine whether the calcium phosphate (CaP) sol-gel coating would have a significant impact on osteoconduction.Methods Porous-surfaced Ti-6Al-4V implants were prepared with or without the addition of a thin surface layer of CaP applied by sol-gel coating,and implanted into the tibiae of 16 rabbits.Implanted sites were allowed to heal for 2 weeks,after which specimens were retrieved for morphometric assessment using backscatter SEM micrographs and a Bioquant Image Analysis System.Results Absolute contact length (ACL) was significantly (P< 0.01) higher for CaP-coated implants (1.18 mm) than for the non-coated implants (0.74 mm) as were the contact length fraction (CLF) (40.4% vs 27.0%, P< 0.01) and Straight line bone growth (SLBG) (1.19 mm vs 1.04 mm, P< 0.01).Conclusion[WT5”BZ] Based on the findings in this study,the addition of a thin layer of CaP to the implant can promotes bone healing around porous-surfaced implants even after only two weeks of initial healing.