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人脂肪组织抵抗素mRNA的表达与代谢综合征无关 被引量：2

Expression of resistin mRNA in human adipose tissue is not related to metabolicsyndrome
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摘要 用一步法半定量RT-PCR技术检测2型糖尿病代谢综合征患者、非糖尿病代谢综合征患者以及正常对照者大网膜及腹部皮下脂肪组织抵抗素mRNA表达。结果显示脂肪组织抵抗素mRNA表达与代谢综合征无关。 The mRNA expression levels of resistin in omental and abdominal subcutaneous adipose tissues were measured by one-step semi-quantitative RT-PCR in normal controls and metablic syndrome patients with or without type 2 diabetes. The results suggest that there is no relationship between resistin mRNA expression in omental and abdominal subcutaneous adipose tissue and metablic syndrome.
作者 杨亚超 王颜刚 阎胜利 张惠然 周玉萍
机构地区 威海市立医院内分泌科 青岛大学医学院附属医院内分泌科
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2005年第3期257-258,共2页 Chinese Journal of Endocrinology and Metabolism
关键词 人脂肪组织抵抗素 MRNA 基因表达 代谢综合征 RT-PCR技术 2型糖尿病 Metabolic syndrome Resistin Reverse transcription polymerase chain reaction Adipose tissue
分类号 R589 [医药卫生—内分泌]
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参考文献8

  • 1Steppan CM, Bailey ST, Bhat S, et al. The hormone resistin links obesity to diabetes. Nature, 2001,409:307-312.
  • 2章建梁,秦永文,郑兴,邱健力,毛红娟,龚莉,邹大进.不同糖耐量状态的原发性高血压患者血清抵抗素水平[J].中华内分泌代谢杂志,2002,18(3):233-235. 被引量：66
  • 3Way JM, Gorgun CZ, Tong Q,et al. Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists. J Biol Chem, 2001,276:25651-25653.
  • 4Savage DB, Sewter CP, Klenk ES, et al. Resistin / Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans. Diabetes, 2001,50:2199-2202.
  • 5Janke J, Engeli S, Gorzelniak K, Resistin gene expression in human adipocytes is not related to insulin resistance. Obes Res, 2002,10:1-5.
  • 6Nagaev I, Smith U. Insulin resistance and type 2 diabetes are not related to resistin expression in human fat cells or skeletal muscle. Biochem Biophys Res Commun, 2001,285:561-564.
  • 7王绍云,宋怀东,李荣英,唐金凤,李凤英,周丽斌,杨颖,胡仁明,牟波,陈名道.高脂大鼠抵抗素基因的上调表达及与胰岛素、瘦素的相关性[J].中华内分泌代谢杂志,2003,19(3):191-193. 被引量：10
  • 8Fain JN, Cheema PS, Bahouth SW, et al. Resistin release by human adipose tissue explants in primary culture. Biochem Biophys Res Commun, 2003,300:674-678.

二级参考文献9

  • 1Zhang Y, Proenca R, Mallei M, et al. Positional cloning of the mouse obese gene and its human homologue. Nature, 1994.372:425-432.
  • 2Banerjee RR, Lazar MA. Dimerization of resistin and resistin-like molecules is determined by a single cysteine. J Biol Chem, 2001,276:25970-25973.
  • 3Lijnen HR, Maquoi E, Holvoet P, et al. Adipose tissue expression of gelatinases in mouse models of obesity. Thromb Haemost, 2001.85:1111-1116.
  • 4Yamauchi T, Kamon J, Waki H, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med, 2001,7:941-946.
  • 5Steppan CM, Bailey ST, Bhat S, et al. The hormone resistin links obesity to diabetes. Nature, 2001,409:307-312 .
  • 6McTeman PG, McTeman CI,, Chetty R, et al. Increased resistin gene and protein expression in human abdominal adipose tissue. J Clin Endocrinol Metab, 2002,87:2407-2415.
  • 7Shuldiner AR, Yang R, Gong DW. Resistin, obesity and insulin resistance-the emerging role of the adipocyte as an endocrine organ. New Engl J Med, 2001,345 : 1345-1346.
  • 8Nagaev I, Smith U. Insulin resistance and type 2 diabetes are not related to resistin expression in human fat cells or skeletal muscle. Biochem Biophys Res Commun ,2001,285:561-564.
  • 9陈名道.Resistin——肥胖与糖尿病的主要连结点?[J].中华内分泌代谢杂志,2001,17(5):267-267. 被引量：24

共引文献74

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中华内分泌代谢杂志
2005年 第3期

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