病毒性肝炎患者血清Ⅲ型前胶原、脯氨酸肽酶和肿瘤坏死因子的检测及其意义分析

Serum PC Ⅲ, PLD and TNF Concentrations in Patients with Viral Hepatitis and an Analysis of its Significance

采用放射免疫分析对８１例病毒性肝炎患者血清Ⅲ型前胶原（ＰＣⅢ）浓度进行了检测，并探讨了它与血清脯氨酸肽酶（ＰＬＤ）活性，肿瘤坏死因子（ＴＮＦ）水平及血清白蛋白之间的关系。结果发现，各型肝炎的ＰＣⅢ浓度均有不同程度的增高（Ｐ＜０．０１），而以慢活肝与急性肝炎最为明显，且两者的ＰＣⅢ异常率也均在７０％以上。血清ＰＣⅢ浓度与血清白蛋白的高低呈负相关（ｒ＝－０．３３０９，Ｐ＜０．００２）。在慢性肝炎中，血清ＰＣⅢ浓度与ＰＬＤ活性高低有关，且与ＴＮＦ水平呈明显负相关。本文对其可能机制进行了初步分析。

Serum concentrations of procollagen Ⅲ (PC Ⅲ) and its relationship with proline peptidase (PLD), tumor necrosis factor (TNF) and serum albumin were investigated in 81 patients with viral hepatitis. Serum levels of PC Ⅲ were variously elevated in different types of viral hepatitis, being most prominent in chronic active hepatitis and acute viral hepatitis with a positive rate of over 70%. The serum PC Ⅲ level was inversely correlated with serum albumin concentration (r=0. 3309, P<0. 002), and with that of TNF (r=-0. 6993,P<0. 01) in chronic hepatitis. correlation was also found between serum PC Ⅲ level and PLD activity. Possible mechanism and significance of these changes are discussed.