多囊卵巢综合征患者外周血生长激素水平测定

Serum growth hormone lcvels in polycystic ovarian syndrome

为了解多囊卵巢综合征肌（ＰＣＯＳ）患者生长激素（ＧＨ）水平，对２１例（肥胖１０例，非肥胖１１例）ＰＣＯＳ患者进行外周血ＧＨ测定，并以２６名（肥胖１２名、非肥胖１４名）正常月经周期妇女作对照。结果：（１）ＰＣＯＳ患者ＧＨ含量（肥胖组０．９１±０．３５ｐｇ／Ｌ，非肥胖组１．３４±０．４９μｇ／Ｌ）较相应正常对照组（肥胖组１．８６±０．５８μｇ／Ｌ，非肥胖组２．１１±０．８８μｇ／Ｌ）降低（Ｐ＜０．０１，Ｐ＜０．０５）。（２）ＰＣＯＳ患者肥胖组较非肥胖组ＧＨ明显降低。认为ＰＣＯＳ患者伴ＧＨ相对不足，可能与下丘脑生长抑素活性。

To investigate growth hormone(GH)levels in women with the polycystic ovarian syndrome(PCOS),serum GH concentrations were measured in 21 PCOS patients(obese n=10, nonobese n=11)and 26 women with regular menses(obese n= 12,nonobese n=14),The results revealed that:(1)serum GH concentrations were decreased significantly in both PCOS groups(obese 0.9l ± 0.35μg/ L,nonobese l.34 ± 0.49μg/L)compared with controls(obese 1.86 ± 0.58pg/L,nonobese 2.11± 0. 88μg/).(2)GH levels were lower in obese PCOS patients than in the nonobese These findings sug-gested relative GH insufficiency was present in PCOS patients,it may be related to somatostatin,obesity and hyperinsulinema.