硅橡胶长期堵塞兔输卵管对妊娠及输卵管平滑肌收缩活动的影响

Effects of oviductal occlusion with silicone rubber on pregnancy and smooth muscle contractility of oviducts in rabbit

通过特制的推进器向雌兔输卵管内注入糊状单组分医用硅橡胶０．２～０．３ｍｌ，３～１７个月后分别观察其妊娠及输卵管峡部平滑肌收缩活动。结果：（１）对照组全部妊娠（仔数平均为６．０只），双侧堵塞组全部未妊娠（无仔），单侧堵塞组也全部妊娠（剖腹检查堵塞侧无妊娠，对照侧全部妊娠，仔数平均为１．５只）；（２）经硅橡胶堵塞输卵管仍保持自发收缩能力，环层肌收缩活动略有减弱；（３）经硅椽胶堵塞输卵管峡部平滑肌对外源性去甲肾上腺素、前列腺素的敏感性未改变，呈现良好的剂量－反应关系。以上结果表明，单组分医用硅橡胶堵塞输卵管能阻止精子与卵子相遇，具有明显的抗育作用，而且对输卵管平滑肌收缩活动无明显影响。

This study is to investigate the pregnancy and contraction of rabbit oviductal isthmicsmooth muscle after injection of a single ingredient of medical silicone rubber 0.2～0.3ml for 3 to 17 months. The restults are as follows:(1)Silicone rubber occluding rabbit oviduct had fine antifertility effect.Allrabbits in the control group were pregnant with an average of six embryos.No pregnancy occurred inbilaterally occluded group. In the unilaterally occluded group,there was no pregnancy at the occludedside: pregnancy at the control side occurred with significantly decreased number of embryos(average 1.5).(2)The oviductal smooth muscle of isthmus retained strong spontaneous contractility after occlusion,butthe amplitude of circular smooth muscle contraction decreased slightly,(3)The response of smooth mus-cle of oviductal isthmus after occlusion to exogenous NE and PGF2χ revealed no obvious change.The results indicate that good antifertility efficacy can be achieved by using a single ingredient medi-cal silicone rubber,through the blockage of oviduct and the prevention of sperms ova interaction,whilethere is no obvious effects on oviductal smooth muscle contractility.