药物的肝脏损害

Drug-induced hepatic injury

目的:药物诱发肝毒性的新认识。方法:复习近几年文献。结果:肝脏是药物代谢的主要器官,美国近期有50%急性肝衰是由药物引起的,上市后药物的停用主要原因也是药物的肝损害,为改善这一状况应对药物肝毒性有一较好的了解。结论:应了解药物诱发肝毒性的病理,药物引起的肝不良反应,以及新药的审批过程。

Objective: To reveal the new recognition of drug-induced hepatotoxicity. Methods: The literature in the recent years are reviewed. Results: The liver is the important organ for the drug metabolism. Drug-induced hepatic injury accounts for more than 50% of the cases of acute liver failure in the USA in recent years and is the most frequent reason for an approved drug withdrawal from the market. In order to improve this condition it is necessary to carry out a comprehensive investigation of drug hepatotoxicity. Conclusion: The pathogenesis of drug-induced hepatotoxicity, adverse drug reactions that involve the liver, and the process of drug approval should be understood.