药源性神经肌肉疾病

Neuromuscular diseases induced by drugs

临床医生认识药源性神经肌肉疾病具有重要意义。药源性神经肌肉疾病的诊断主要通过病史、体格检查、血液检查、电生理检查、肌肉和神经活检。作者综述已知明确能诱发神经肌肉疾病的药物,描述常见的症状和体征,探讨其可能的致病机制。

It is importment for clinicians to be aware of iatrogenic neuromuscular disorders. Patients suspected of having drug-induced neuromuscular disorders are diagnosed through comprehensive medical history, physical examination, proper blood workup, electrophysiological studies, and, if necessary, muscle or nerve biopsy. In this paper, the drugs that are known to induce muscle and/or nerve toxicity are reviewed, the commonly encountered signs and symptoms are described, and the mechanisms underlying these iatrogenic effects are discussed.