2型糖尿病血清尿酸与血糖、血脂关系的探讨

Investigation the Relation Between Serum Uricaeand Blood Lipid and Glucoe in Patients with Diabetes Type 2 Patients

目的了解2型糖尿病患者的血清尿酸与血糖、血脂的关系。方法设立2型糖尿病组和非糖尿病对照组,2型糖尿病组132例,非糖尿病对照组120例,对两组的血清尿酸水平与血糖、血脂的关系进行检测分析。结果2型糖尿病组血清尿酸的水平较非糖尿病对照组降低(P<0.01),2型糖尿病患者血清尿酸水平与血糖呈负相关(r=-0.235,P<0.05)。2型糖尿病组的血脂代谢异常的检出率较非糖尿病对照组高。结论提示2型糖尿病患者血清尿酸水平降低可能与高血糖的高渗性利尿作用有关,高血糖的渗透性利尿使尿酸的排泄增加,高尿酸血症本身可能不是长期糖尿病患者动脉硬化的独立危险因素。

Objective Investigate the relation between the serum uricae and blood glucose blood lipid.Methods To establish a patient group which consists of 132 patients with diabetes type 2 and a control group which has 120 normal persons.Analyze the relations between the level of uricae and blood glueose,ulicae and blood lipid.Results In comparition to the control group,the uricae of the patient group is decreased (P<0.01),which shows a negative correlation (r=-0.235,P<0.05 ).The ratio of the abnormal lipid mefabolism is higher in the patient group than in the control group.Conclusion It is suggested that the decrease of the patients' serum uricae may be resulted from the hyperosmotic duresis of the hyperglycemia since the hyperosmotic duresis accelerates the excretion of uricae,hyperuricuria might not be the only risk factor which causes the atherosclerosis of the patient with lovy history of diabetes.