硫酸镁对新生儿缺氧缺血性脑病智能发育的影响

Affect of Salamarum on Intelligence Development in Hypoxic Ischemic Encephalopathy of Neonates

目的探讨硫酸镁治疗对新生儿缺氧缺血性脑病(HIE)智能发育的影响。方法将102例HIE患儿随机分为两组,观察组58例、对照组44例,两组给予相同综合治疗,观察组加用25%硫酸镁,疗程7d。两组治疗前后行NBNA检查(平均间隔12d),并用丹佛发育筛查法进行随访。结果治疗前两组间NBNA检查结果差异无显著性,而治疗后两组间差异显著(χ2=3.93,P<0.05),随访发现智能发育落后者观察组2例,对照组6例,存在显著性差异(χ2=3.95,P<0.05)。结论早期应用硫酸镁治疗HIE有利于智能发育的恢复。

Objective To detect the affect of salamarum therapy on intelligence development in hypoxic ischemic encephalopathy of neonates (HIE).Methods 102 cases of HIE were divided into two groups randomly,58 cases in observation group and 44 cases in comparison group.Both groups were given same general treatment,and observation group was given additional 7 days salamarum therapy.Both groups were given NBNA examination before and after treatment (mean interval was 12 days),also given DDST examination for follow-up.Results There was significant difference between two groups in NBNA results before treatment,but the difference was significant between two groups in NBNA results (χ2=3.93,P<0.05) after treatment and in DDST (χ2=3.95,P<0.05) examination results.Two cases in observation group and 6 cases in comparison group of delayed intelligence development were found.Conclusion Early salamarum therapy in HIE is helpful for intelligence development rehabilitation.