LEP,IGF-1和TNFα测定对乳腺癌患者的临床意义

Clinical Significance of Detection of Serum Leptin,Insulin-Like Growth Factor-1 and Tumor Necrosis Factor α in Breast Cancer Patients

目的乳腺癌患者血清瘦素(LEP)、胰岛素样生长因子-1(IGF-1)、肿瘤坏死因子α(TNFα)测定的临床意义。方法用放射免疫分析法(RIA)和免疫放射分析法(IRMA)测定良性、恶性乳腺病变患者和正常对照者血清LEP,IGF-1和TNFα的浓度。结果LEP,IGF-1和TNFα的浓度在乳腺癌患者与正常对照者之间差异均有显著性。结论LEP,IGF-1和TNFα浓度测定有助于乳腺癌的诊断、治疗和研究。

Objective To research the clinical significance in the detection of serum leptin(LEP),insulin-like growth factor-1(IGF-1) and tumor necrosis factor α(TNFα) in breast cancer patients.Methods Using RIA and IRMA method to detect the serum concentrations of LEP,IGF-1,TNFα in breast cancer patient,breast benign lesion patients and normal controls.Results Serum concentrations of LEP,IGF-1,TNFα in breast cancer patient were obviously different from that of normal control group.Conclusion Detection of the serum concentrations of LEP,IGF-1,TNFα is useful for diagnosis,treating and research of breast cancer.