结合HBV血清学标志和肝内抗原的形态分布探讨与HBV复制、病变程度及预后的关系

ASTUDY COMBINING HBVSEROLOGICAL MARKS WITH PATTERNS AND DIDTRIBUTIONS OF HBAgINLIVERINREFLECTINGHBVREpLICATION,LESI0NDEGREE0FLIVERANDPROGN0-SIS.

通过慢性乙型肝炎和重型乙型肝炎病人肝内ＨＢｓＡｇ和ＨＢｃＡｇ的形态和分布观察，发现血清病毒学标志和肝内病毒抗原特殊形态分布所反映的病毒复制状态是一致的。病毒抗原在肝细胞内的形态和分布与肝炎病变程度密切相关。重型肝炎肝内ＨＢＶ抗原检出低，其预后差，形态分布以ＨＢｓＡｇ膜型、核周分布和ＨＢｃＡｇ浆型为主。核周分布仅见于亚大块坏死灶旁或灶中。

We observed the patterns and distributions of HBcAg inliver of patients with chronic and fulmi-nant hepatitis B and found that special patterns and distributions of HBAg in liver were consistent with sero-logical marks of hepatitis B virus in reflecting virus replication。 There was a significant relationship between patterns and distributions HBAg in liver and lesion degree of liver。 HBAg in liver of patients with fulminant hepatitis was detected in low rate but prognosis was ba. Membranous, neuclear-around HBsAg and cytoplas-mic HBcAg patterns were mainly observed in fulminant hepatitis。 Neuclear-around pattern of HBsAg was only bund in or beside submassive necrosis。