联合应用ACEI和β受体阻滞剂治疗充血性心力衰竭的疗效观察

The Clinical Efficacy of ACEI Combined with βReceptor Antagonistin the Treatment of Congestive Heart Failure

目的:观察常规治疗基础上联合应用卡托普利和倍他乐克对充血性心力衰竭的疗效。方法:选择94例充血性心力衰竭(CHF)患者,随机分为对照组(n=4 6 )和观察组(n=4 8) ,对照组予以常规治疗,观察组在常规治疗的基础上,加用卡托普利和倍他乐克,疗程8周。比较两组疗效。结果:观察组4 4例有效,总有效率为91.6 7% ,对照组35例有效,总有效率为76 .0 9%。两组间比较有显著性差异(P<0 .0 1)。观察组的收缩压、舒张压、心率较对照组有明显下降(P<0 .0 1) ,左室射血分数上升(P<0 .0 1)。结论:常规治疗基础上加用卡托普利和倍他乐克能有效改善CHF患者的心功能,疗效优于常规治疗。

Objective:To observe the clinical efficacy of using captopril combined with betaloc on the basis of routine treatment of congestive heart failure.Methods:94 patients with CHF were collected and divided into two groups randomly.In experimental group,48 patients were treated with betaloc and captopril besides routine therapy,and in control group,46 patients were treated with only routine therapy.After 8 weeks of follow-up,the clinical efficacy was compared between the two groups.Results:44 patients showed improved symptoms in experimental group with the total effective rate of 91.67%,significantly higher than that in control group.Also significant differences were found in the SBP, DBP,HR and EF between the two groups(P<0.01).Conclusions:Our data suggested that using captopril combined with betaloc on the basis of routine therapy was better than only routine therapy in the treatment of congestive heart failure.