非小细胞肺癌组织中Survivin、MVD基因的表达及对预后的影响

Expressions of Survivin, microvessel density in non-small cell lung cancer and their correlation with prognosis

目的:研究非小细胞肺癌组织中Survivin、MVD基因的表达及其对预后的影响。方法:应用免疫组化S-P法检测肺癌、癌旁及肺良性瘤样病变组织中Survivin、MVD的表达,分析两项指标对患者预后的影响。结果:肺癌、癌旁及肺良性瘤样病变组织中Survivin表达率为69.7%穴63/96雪、16.1%穴5/31雪、0穴0/20雪穴P<0.05雪,MVD值为24.44±7.79、19.37±5.26和11.83±6.52(P<0.05);Survivin、MVD阳性组术后生存期明显短于阴性组穴P=0.042,P=0.039雪。结论:肺癌组织中Survivin、MVD的表达明显高于癌旁和肺良性瘤样病变组织,其表达与肺癌患者的预后有关,是判断预后的良好指标。

Objective: To study the expressions of survivin, MVD in non-small cell lung cancer (NSCLC) and their correlation with prognosis. Methods: Expressions of survivin, MVD and their correlation with prognosis were detected by streptavidin-peroxidase (S-P) method in NSCLC, adjacent tumor tissues and benign lesions. Results: The expression rate of survivin, in NSCLC, adjacent tumor tissues and benign lesions was 69.7%(63/96), 16.1%(5/31) and 0(0/20)(P<0.05);the expression value of MVD was 24.44±7.79, 19.37±5.26 and 11.83±6.52 respectively(P<0.05). The survival of NSCLC was associated with expressions of survivin and MVD (P=0.042, P=0.039). Conclusion: Survivin, MVD are overexpressed in NSCLC and their expressions are related with prognosis.