组织蛋白酶在宫颈鳞癌中的表达及临床意义

A Study on Cath-D Expression of Cervical Squamous Cell Carcinoma

目的探讨组织蛋白酶(Cath-D)在宫颈鳞癌中的表达及其意义。方法应用免疫组化法检测31例宫颈上皮内瘤样病变(CIN)、71例宫颈浸润鳞癌组织(ICC)及23例正常子宫颈、慢性宫颈炎组织标本中Cath-D的表达。结果Cath-D在正常宫颈组织鳞状上皮基底层有少量弱阳性表达,表达率为21.74%;在CIN组中表达率为16.13%,与对照组比较无明显差异(P>0.05)。Cath-D在ICC组中表达率为54.93%,较对照组表达明显增加(P<0.05);在宫颈鳞癌中Cath-D总表达率为48.28%,且与组织分化程度显著相关(P<0.01),与淋巴结转移也明显相关(P<0.05)。结论Cath-D在宫颈鳞癌中有较高的表达率,组织分化程度越低、有淋巴结转移者,表达率越高。

Objective To investigate the Cath-D expression of cervical s quamous ce ll carcinoma and clinical significance. Methods To detect Cath-D in 31 cases of cervical intraepithelial neoplasia(CIN), 71 cases of cervical squamous cell carc inoma(ICC), 23 samples of dysplasia of cervical epithelium and normal cervical t issues by means of immunohistochemistry. The relationship between Cath-D expres s ion and clinicopathologic factors was analyzed by Chi-square test. Resul ts The expression rate of Cath-D, in normal cervical tissues and CIN, was 21.74% and 1 6. 13%, respectively (P>0.05). The expression rate of Cath-D in ICC was 54. 93%, muc h higher than normal cervical tissues(P<0.05). That in car cinom as was 48.28% and correlated with cellular differentiation(P <0.01 )and lymph nodes metastasis( P<0.05). Conclusion The res ults suggest that th e expression of Cath-D is closely correlated to generation,development, invasio n and metastasis of cervical squamous cell carcinoma.