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新发现的抗HIV-1蛋白质TRIM5α研究进展

A noval TRIM5α protein blocking infection by HIV-1:research advances
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摘要 TRIM5α是一种具有3个结构域的胞浆体蛋白质。新近发现猿猴细胞中的TRIM5α具有抗HIV-1的作用,从而使TRIM5α的研究引起广泛关注。本文对TRIM5α的分子结构特点、抗HIV1的作用、抗病毒机制及其相似蛋白质的功能等方面的最新研究进展作一综述。 TRIM5α ,belonging to the RBCC (ring finger domain,B-box domain and coiled-coil domain) protein family,is a cytoplasmic body protein with three domains.Recently, a newly discovered function of TRIM5α isolated from Rhesus monkey is the potential restriction of HIV-1 and this exciting discovery has attracted widespread attention in the world. In this review, some new advances in research on TRIM5α protein including restriction of HIV-1,molecular characterization, potential antiviral mechanism and its related proteins are reviewed.
作者 胡巍 凌世淦
机构地区 军事医学科学院基础医学研究所
出处 《军事医学科学院院刊》 CAS CSCD 北大核心 2005年第3期287-290,共4页 Bulletin of the Academy of Military Medical Sciences
基金 国家"十五"重点科技攻关计划资助(2001BA705B060)
关键词 三结构域蛋白50α HIV抗体 抗病毒机制 TRIM5α HIV antibodies antivirus mechanism
分类号 R346 [医药卫生—基础医学]
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军事医学科学院院刊
2005年 第3期

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