微波辐射下合成2-氨基-5-芳氧亚甲基-1,3,4-噻二唑

Synthesis of 2,5-disubstituted-1,3,4-thiadiazole under Microwave Irradiation

在三氯氧磷作用下,由芳氧基乙酸和氨基硫脲经脱水环合,微波辐射快速合成了一系列2氨基5芳氧亚甲基1,3,4噻二唑类化合物.目标产物的结构经红外光谱及熔点测定得到确证.该方法具有反应时间短、操作简便、副产物少、产率高、易纯化及环境友好等优点.

The reaction of aryloxy acetic acid with thiosemicarbazide in the presence of dehydrating agent,POCl_3,affords a series of 2amino5aryloxymethyl1,3,4thiadiazoles under microwave irradiation (MWI). 2,5disubstituted1,3,4thiadiazoles have attracted much attention due to their diverse biological activities,such as antimicrobial,antibacterial,anesthetic,anticonvulsant,antiinflammatory and antiulcer activities.Compared with classical methods,this method has the advantages of high yields,short reaction time,easy preparation and mild reaction conditions.The structures of compounds were characterized by analyzing melting points and IR.