糖尿病亲属中糖耐量正常者血糖水平的漂移变化分析

Variation Analysis of the Glycemic Excursions in Siblings of Diabetes Mellitus with Normal Glucose Tolerance

目的探查糖尿病亲属中糖耐量正常者1d内血糖水平漂移变化过程。方法采用动态血糖监测系统(CGMS)对50例糖尿病亲属的糖耐量正常者进行连续72±7小时血糖监测。结果平均血糖值5.3±0.5mmol/L;1d内血糖的峰、谷值分别为7.8±1.4mmol/L、3.9±0.7mmol/L;血糖漂移>7.8mmol/L占64%;血糖漂移<2.8mmol/L占22%。血糖漂移于2.8～7.8mmol/L的时间比例达99%。结论该研究结果有助于较为详细地认识糖尿病亲属糖耐量正常者的血糖漂移变化,及时发现无症状的高血糖和低血糖。并对探讨糖尿病诊断的分割点及血糖控制目标具有重要意义。

Objective To probe variation on the daily glycemic excursions in siblings of diabetes mellitus with mormat glucose tolerance.~Methods The fluctuation of blood glucose level in 50 siblings of diabetes mellitus with normal glucose tolerance were measured by continuous glucose monitoring system(CGMS) for (72±7) hours.~Results The average glycemic value was 5.3 mmol/L.The daily glycemic peak and nadir levels were (7.8±1.4) mmol/L and(3.9±0.7) mmol/L.64% showed glycemic excursion above 7.8 mmol/L,22% showed brief glycemic excursion below 2.8 mmol/L.During daytime the glycemic level drifted to and fro between 2.8 mmol/L and 7.8 mmol/L.Conclusion The variation of glycemic excursion in siblings of diabetes mellitus with normal glucese tolerance may be of important significance in discovering asymptomatic hypeglycemic and hyplglycemic,defining the diagnostic cut-points,and targets for glycemic control on diabetes mellitus.