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重复经颅磁刺激对大鼠海马、齿状回胶质纤维酸性蛋白、Ⅲ型补体受体表达的影响 被引量：2

Effects of repetitive transcranial magnetic stimulation on GFAP and OX-42 expression in hippocampus and dentate gyrus in rats
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摘要 目的观察重复经颅磁刺激(rTMS)对大鼠海马、齿状回星形胶质细胞和小胶质细胞标记物胶质纤维酸性蛋白(GFAP)、Ⅲ型补体受体(OX42)表达的影响。方法每日1次给予大鼠1Hz、100mT的TMS10min,共14d,观察大鼠行为的变化;14d后采用免疫组化ABC法检测其海马、齿状回GFAP、OX42的表达,并与对照组比较。结果rTMS组、对照组大鼠海马、齿状回GFAP、OX42阳性表达物在形态、数量等方面差异无显著性。结论本实验条件下的rTMS不会造成大鼠中枢神经系统明显损伤。 Objective To observe the effects of repetitive transcranial magnetic stimulation (rTMS) on the expression of glial fibrillary acidic protein (GFAP) and OX-42 in hippocampus and dentate gyrus in rats.Methods The rats were treated with 1 Hz, 100 mT TMS 10 min once a day for 14 days, and then the expression of GFAP and OX-42 in hippocampus and dentate gyrus were investigated by ABC technique of immunohistochemistry.Results Compared with the control group, there were no significant difference in the expression of GFAP and OX-42 between the two groups.Conclusion rTMS using our parameters does not cause brain injury in rats.
作者 魏莉 林宏 李柱一 刘煜
机构地区 第四军医大学唐都医院神经内科
出处 《临床神经病学杂志》 CAS 北大核心 2005年第3期199-200,共2页 Journal of Clinical Neurology
关键词 重复经颅磁刺激 胶质纤维酸性蛋白 Ⅲ型补体受体 repetitive transcranial magnetic stimulation GFAP OX-42
分类号 R741 [医药卫生—神经病学与精神病学]
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参考文献9

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共引文献3

同被引文献22

  • 1丁迎,苏邹,陈钰,戢秋明.不同模式的重复经颅磁刺激对精神分裂症阴性症状和社会功能的影响[J].中国急救医学,2018,38(A01):122-122. 被引量：6
  • 2张小乔,梅元武,刘传玉.经颅磁刺激后脑梗死大鼠学习记忆与海马c-Fos的表达[J].中国临床康复,2005,9(16):98-100. 被引量：4
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  • 10彭焱,李建明,王健,邹义壮,谭淑平,张进国,陈楠,范宏振,崔介峰.慢性精神分裂症事件相关电位P300与认知功能成套测验的研究[J].中国健康心理学杂志,2009,17(9):1025-1028. 被引量：10

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二级引证文献16

临床神经病学杂志
2005年 第3期

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