颅高压状态下颅压波动低频成分的实验研究

Experimental study of low frequency component of intracranial pressure fluctuation during intracranial hypertension

目的研究颅高压状态下颅压波动中低频成分的变化。方法将15条狗安置硬膜外球囊并注入液体制成颅高压模型。通过球囊内液体量的变化导致不同程度的颅内压力及颅内容积的改变,压力传感器持续记录脑室内压力和腰椎管内压力,频谱分析方法分析所有颅压波动段中低频成分的变化。结果颅内容积增加及颅压升高后,颅压波动段中可出现频率0.1～0.2Hz的M波。结论M波的出现提示颅内顺应性下降,颅内容积代偿能力开始衰竭。

Objective To study the changes of low-frequency-component of intracranial pressure (ICP) fluctuation during intracranial hypertension. Methods 15 healthy mongrel dogs were used to make models of intracranial hypertension by arranging latex sacculus epidurally.The different amount of normal that was injected into latex sacculus led to fluctuation of ICP and alteration of intracranial volume. The pressures in ventricle and lumbar spinal canal were recorded continuously by baroceptor, and the changes of low-frequency-component of ICP fluctuation were studied by frequency-spectrum analysis. Results After increase of intracranial pressure and volume,pulse wave (M wave) with its frequency at 0.1～0.2 Hz showed continually. Conclusion Emerge of M wave may reflect some decrease of intracranial compliance and the beginning of volume compensation failure.