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吉西他滨联合顺铂治疗恶性肿瘤临床观察 被引量:1

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摘要 目的观察吉西他滨联合顺铂治疗恶性肿瘤近期疗效和毒副反应。方法9例非霍奇金氏淋巴瘤患者采用GP方案加强的松(吉西他滨1000mg/m2d1.8;顺铂25mg/m2d1-3;强的松片60mg/m2d1-5),其他36例恶性肿瘤患者采用GP方案(剂量用法同上)。结果CR8.89%(4/45),PR42.2%(19/45),总有效率51.1%(23/45)。毒副反应中Ⅲ~Ⅳ°白细胞减少为33.3%,血小板减少为24.4%,贫血13.3%,恶心呕吐35.6%。结论吉西他滨联合顺铂治疗恶性肿瘤疗效高,毒副反应少,值得临床进一步研究和推广。
出处 《江西医药》 CAS 2005年第6期346-347,共2页 Jiangxi Medical Journal
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  • 1[1]Larry WH,George BB,Stan J,et al.Evaluation of the antitumor activity of gemcitabine[J].Cancer Res,1990,50(14) :4417-4422.
  • 2[2]James LA,Ralf G,Earle AW,et al.A Phase Ⅰ clinical,plasma and cellular parmacology study of gemcitabine[ J].J Clin Oncol,1991,9(3) :491-498.
  • 3[3]Boudewijn JM,Braakhuis GA,Jan BV,et al.Preclinical in vivo activity gemcitabine against human head and neck cancer [ J].Cancer Res,1991,51(1) :211-214 .
  • 4[4]James LA.Phase I studies with the novel nucleoside analog gemcitabine[ J].Semin Oncol,1996 10(Suppl 23 ): ,25-31.
  • 5[5]Anderson H,Lund B,Bach F,et al.Single-agent activity of weekly gemcitabine in advanced non-small-cell lung cancer: a phase Ⅱ study[J].J Clin Oncol ,1994,12(9): 1821-1826.
  • 6[6]Paymond PA,Werner RB,Geoffvey F,et al.Efficacy and safety profile of gemcitabine in non-small-cell lung cancer: a phase Ⅱ study[ J ].J Clin Oncol,1994,12(8): 1535-1540.
  • 7[7]Gatzemeier R,Shepherd FA,Chevalier TL,et al.Activity of gemcitabine in patients with non-small-cell lung cancer[ J ].Eur J Cancer,1996,32 ( 1 ): 243 -248.
  • 8[8]Fukuoka M,Takada M,Yokoyama A,et al.Phase Ⅱ study of gemcitabine for non-small-cell lung cancer in Japan [ J ] .Semin Oncol,1998,25 ( Suppl 7 ): 42-46.
  • 9[9]Crino L,Scagliotti G,Marangolo M,et al.Cisplatin-gemcitabine combination in advanced non-small-cell lung cancer: a phase Ⅱ trail[J].J Clin Oncol ,1997,15(1):297-303.
  • 10[10]Lucio C,Anna MM,Giorgio VS,et al.Gemcitabine as second-line trentment for relapsing or refractory advanced non-small-cell lung cancer:a phase Ⅱ trail[J].Semin Oncol,1998,25(Suppl 9):23-26.

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