肺癌患者血清中SC3A-6抗原的检测及其临床意义

Examination of SC3A-6A in Serum of lung cancer patients and its clinical significance

目的探讨肺癌患者血清中SC3A6抗原的含量及临床意义。方法应用双抗体酶联免疫吸附试验(ELISA)对205例肺癌患者、100例良性病变者和80例正常人的血清进行SC3A6抗原检测。结果肺癌组的A492nm平均值为0.655±0.299,良性病变为0.285±0.137,正常对照组为0.246±0.129。SC3A6阳性率分别为70.7%、6.0%和5.0%,肺癌组与良性病变、正常对照组比较差异均有显著性(P<0.001),良性病变与正常对照组比较差异无显著性(P>0.05)。结论SC3A6抗原的含量随着病情的进展而增加,因此检测该抗体对肺癌的早期诊断、监测病情、判断预后等具有重要的临床价值。

Objective To study the content of SC3A-6 in serum of lung cancer patients and its clinical significance.Methods 205 cases of lung cancer,100 cases of benign lesion and 80 normal people were studied.ELISA was used to observe content of SC3A-6 in their serum.Results The soluble SC3A6 antigen in sera was found in 70.7% of patients with lung cancer,6.0% of patients with benign lesions,and 5.0% of normal persons.The results showed that the content of antigen SC3A-6 in lung cancers was significantly higher than those in benign lesion and normal persons (P<0.001).Conclusions The content was increased with the progression of the disease.Therefore detection of SC3A-6 might be helpful to diagnosis,assessing therapeutic effectiveness and judging prognoses.