血管紧张素转化酶2——一种新的肾素-血管紧张素系统的重要调节剂

ACE2——A New Important Regulator of Renin-Angiotensin System

血管紧张素转化酶-2是新发现的血管紧张素转化酶的同源物,主要分布于心脏、肾脏和睾丸,能降解血管紧张素Ⅰ为血管紧张素1-9,也能降解血管紧张素Ⅱ为有生物活性的舒血管肽血管紧张素1-7。血管紧张素转化酶2在生理和病理生理状态中的重要性目前还不清楚,但初步的研究认为它在调节心血管和肾脏功能中起一定的作用。

Angiotensin-converting enzyme 2(ACE2) is the first newly known human homologue of ACE,and is found predominantly in heart,kidney and testis.ACE2 cleaves a single residue from angiotensin Ⅰto generate angiotension 1-9,and also degrades angiotensin Ⅱ to the vasodilator angiotension 1-7.The importance of ACE2 in normal physiology and pathophysiolgical states is largely unknown.Research proves that ACE2 plays a significant role in regulating cardiovascular and renal function.