眼用表面麻醉液对近视眼角膜厚度的影响(英文)

Corneal thickness is increased after topical anesthesia in myopia

目的:利用OrbscanII眼前节分析系统研究眼用表面麻醉液对近视眼角膜厚度的影响,探讨其在屈光手术角膜厚度测量中的作用。方法:在滴4g/L倍诺喜液前后分别对98例近视眼患者(98眼)的角膜最薄点厚度(THN)、中央2mm直径范围内的平均厚度(CT)以及前房深度(ACD)进行测量。结果:滴4g/L倍诺喜液5min后本组近视眼角膜最薄厚度平均增加3.17±6.88μm(t=-4.569,P<0.001),角膜中央厚度平均增加3.10±7.13μm(t=-4.310,P<0.001),前房深度无显著变化(t=1.288,P=0.201)。结论:眼用表面麻醉液能于短时间内显著影响近视眼的角膜厚度,这有可能对角膜屈光手术的安全性、有效性和可预测性产生一定影响。

· AIM: To study the effects of topical anesthesia on corneal thickness in myopic eyes with Orbscan topography system and to assess the application prospect of this device in determining the corneal thickness for refractive surgery. · METHODS: Corneal thickness was measured before and 5 minutes after administration of one drop of Benoxil (Oxybuprocaine) 4g/L solution (Santen, Japan) to 98 eyes (98 patients). The numeric value of the corneal thinness (THN) and the mean central corneal thickness (CCT) of 2mm in diameter were obtained before and after the instillation. The changes in anterior chamber depth (ACD) were also studied.· RESULTS: THN increased by 3.17±.88μm (t =-4.569, P <0.001) and CCT by 3.10±7.13μm (t =-4.310, P < 0.001) were found following the instillation of the topical anesthetic. There were no statistically significant changes in ACD (t =1.288, P =0.201).· CONCLUSION: Topical anesthesia may have significant immediate effects on the corneal thickness in myopic eyes and this have implications for corneal refractive surgery and even for the accuracy of applanation tonometry.·