不同药物预防晶状体后囊混浊的相关机制及效果

Mechanism and effects of different drugs inhibiting PCO

晶状体后囊混浊(PCO)是白内障行囊外摘除术后最常见的并发症。后囊混浊是因术中残留的晶状体上皮细胞(LEC)增殖和变性纤维化所致[1],尽管混浊的后囊膜可以通过再次手术或激光的方法改善一定视力,但这会破坏晶状体后囊的屏障作用,增加视网膜脱离、黄斑囊样水肿等并发症的发生率。如能用药物抑制晶状体上皮细胞的增殖,则能预防后囊混浊的发生。本文就不同药物预防后囊混浊的相关机制及效果进行综述。

· Posterior capsule opacification (PCO) is a common complication of extracapsular cataract extraction. The opacification is mainly due to the proliferation and fibrous degeneration of lens epithelial cells (LEC) postoperativly remained on the posterior lens capsule. Although vision of the patients can be improved through secondary operation or laser surgery, it will harm the barrier function of posterior capsule and increase the risk of some complication, such as retinal detachment and cystoid macular edema. PCO may be prevented by some inhibition drugs to control the proliferation of LEC. Mechanism and effects of different drugs preventing PCO were reviewed in this paper.·