糖基化在白内障发病中的作用和防治对策

Effect of glycosylation in cataract development and the preventive strategies

晶状体蛋白质糖基化在白内障发生、发展中起的作用已被长期关注。本综述从糖基化的概念、晶状体蛋白的糖基化、晶状体酶和受体的糖基化3方面,系统论述了糖基化的作用机制及其在年龄相关性和糖尿病性白内障形成中的重要作用,并介绍了抑制糖基化的方法,如AGEs形成抑制剂、AGEs交联阻断剂,这些具有针对性的治疗方法为白内障的治疗提出了有效可行的指导依据。

· The effect of lens protein glycosylation in cataract formation and development has long been concerned about. By summarizing the concept of glycosylation, glycosylation of lens crystallin, enzymes and receptors, we attempted to conduct a systematic review of the effect of glycosylation on age-related cataract and diabetic cataract. The preventive strategies to glycosylation, such as advance glycation end product and cross-linking inhibitors, were also summarized to offer an effective and feasible guideline for clinical therapy of cataract.·