期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

TGF-β/Smads信号转导通路与糖尿病视网膜病变 被引量：3

Effects of TGF-β/Smads signaling pathway on diabetic retinopathy
下载PDF
导出
摘要 TGF-β在糖尿病视网膜病变发生发展过程中具有重要的调节作用,Smads蛋白是TGF-β受体的胞内激酶底物,介导了TGF-β的胞内转导。我们综述了近年来TGF-β/Smads信号转导通路与糖尿病视网膜病变发生发展的关系及其所起作用的研究进展,通过对TGF-β/Smads的研究有助于阐明糖尿病视网膜病变的发病机制,从而为防治糖尿病视网膜病变提供了一种新思路。 · Transforming growth factor-β (TGF-β) plays a crucial role in diabetic retinopathy, and Smads mediate the intracellular signal transduction of TGF-β. In this paper we reviewed the relations between TGF-β/Smads signaling pathway and the occurrence and development of diabetic retinopathy. Besides, we studied the research progress of its function recently. Elevated awareness of TGF-β/Smads signaling pathway and increasing information obtained via investigation of them will undoubtedly lead to better understanding of the mechanism of diabetic retinopathy and be helpful for finding a new method to prevent diabetic retinopathy.·
作者 曹丹 柳林
机构地区 第二军医大学长海医院眼科
出处 《国际眼科杂志》 CAS 2005年第3期532-536,共5页 International Eye Science
关键词 TGF-Β/SMADS 信号转导通路 糖尿病视网膜病变 DRP 微血管病变 diabetic retinopathy signal transduction
分类号 R587.2 [医药卫生—内分泌] R774.1 [医药卫生—眼科]
  • 相关文献

参考文献24

  • 1Hammes HP, Lin J, Renner O, Shani M, Lundqvist A, Betsholtz C,Brownlee M, Deutsch U. Pericytes and the pathogenesis of diabetic retinopathy.Diabetes ,2002;51 (10):3107-3112
  • 2Massague J, Chen YG. Controlling TGF-beta signaling. Cenes Dev,2000;14(6):627-644
  • 3Miyazono K, Kusanagi K, Inoue H.Divergence and convergence of TGF-beta/BMP signaling.J Cell Physiol, 2001;187(3):265-276
  • 4Jakowlew SB, Dillard PJ, Sporn MB, Roberts AB. Complementary deoxyribonucleic acid cloning of a messenger ribonucleic acid encoding transforming growth factor beta 4 from chicken embryo chondrocytes. Mol Endocrinol,1988;2(12):1186-1195
  • 5Yamashita H, Tobari I, Sawa M, Hori S, Miyazono K, Heldin CH, Heldin P, Dijke PT, Sampath TK, Suiryu T, Eguchi S, Kitano S, Suzuki S, Ichijo H,Kato M, Yamamoto T, Funazu E, Suzuki M, Ikegami Y, Kato S, Obata H,Horie K, Mogi Y, Seiya K, Sakai H. Functions of the transforming growth factor-beta superfamily in eyes. Nippon Ganka Gakkai Zasshi,1997;101(12):927-947
  • 6Obata H, Kaburaki T, Kato M, Yamashita H. Expression of TGF-beta type Ⅰ and type Ⅱ receptors in rat eyes. Curr Eye Res,1996;15(3):335-340
  • 7Kawabata M, Imamura T, Miyazono K. Signal transduction by bone morphogenetic proteins. Cytokine Growth Factor Rev ,1998;9( 1):49-61
  • 8Zhu HJ, Burgess AW. Regulation of transforming growth factor-beta signaling. Mol Cell Biol Res Commun ,2001;4(6):321 - 330
  • 9Derynck R. TGF-beta-receptor-mediated signaling. Trends Biochem Sci,1994;19(12):548-553
  • 10Moustakas A, Souchelnytskyi S, Heldin CH. Smad regulation in TGF-beta signal transduction. J Cell Sci,2001; 114(24):4359-4369

二级参考文献2

共引文献31

同被引文献40

  • 1李明才,何韶衡.转化生长因子-β在哮喘气道炎症与重塑中的作用[J].中国病理生理杂志,2004,20(8):1527-1530. 被引量：10
  • 2赵宏,张效房.增生性糖尿病视网膜病变玻璃体切除物中MMP-2和MMP-9的表达[J].郑州大学学报（医学版）,2007,42(3):556-557. 被引量：6
  • 3Di Girolamo N,Kumor RK,Coroneo MT,Wakefield D.UVB-medinted induction of inter leukin-6and-8 in pterygia and cultured human pterygium epithelial cell.Invest Ophthalmol Vis Sci,2002;43(11):3430-3437
  • 4Di Girolamo N,Chui J,Coroneo MT,Wakefield D.Pathogenesis of pterygia:role of cytokines,growth factors,and matrix metal oproteinases.Prog Retin Eye Res,2004;23(2):195-228
  • 5Kria L,Ohria A,Amemiya T.Immunohistochemial localization of basic fibroblast growth factor,platelet derived growth factor,transforming growth factor-beta and tumor necrosisfactor-alphainthepterygium.Acta Histochem,1996;98(2):195 -201
  • 6KriaL,Ohria A,Amemiya T.Growth factorsin cultured pterygium fibroblasts.Graefe's Arch Clin Exp Ophthalmol,1998;236(9):702-708.
  • 7Gordon Thomson C,de Iongh RV,Hales AM,Chamberlain CG,MCAvoy JW.DifferentialcataractogenicpotenlyofTGF-beta1,-beta2,and-beta3 and their expression in the postnatal rat eye.invest Ophthalmol Vis Sci,1998;39:1399-1409
  • 8Pasquale LR,Dorman-Pease ME,Lutly GA,Quigley HA,Jampel HD.Immunolocalization of TGF-β1,TGF-β2and TGF-β3 in the anterior segment of the human eye.Invest Ophthalmol Vis Sci,1993;34(1):23-30
  • 9Luo K,Lodish HF.Signaling by chimeric erythropoietin-TGF-betareceptors:homodinmer.zation of the Cytoplasmic Domain of the Type1 TGF-beta receptor and hetero-dimerization with the Type2 receptor are both required for intracellular signal transduation.EMBO J,1996;15(17):4485-4496
  • 10Ten Dijke P,Goumans MT,Itoh F,Itoh S.Regulation of cell proliferationbysmadproteins.J Cell Physiol,2002;191(1):1-16

引证文献3

二级引证文献17

国际眼科杂志
2005年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部