摘要
目的探讨抵抗素与妊娠生理性胰岛素抵抗(IR)和妊娠糖尿病(GDM)的关系。方法以Westernblot法检测妊娠妇女腹部皮下脂肪组织、胎盘及非妊娠妇女腹部皮下脂肪组织的抵抗素蛋白表达情况。结果胎盘抵抗素蛋白的图像分析表达量[(67905±8441)A]明显高于妊娠[(40718±3818)A]和非妊娠妇女腹部皮下脂肪组织[(38288±2084)A](P<0.01),后两组间差异不明显。结论胎盘所分泌的抵抗素高于脂肪组织;抵抗素可能是引起妊娠生理性IR和GDM的因素之一。
Objective To explore the expression of resistin protein in abdominal subcutaneous adipose tissue and placental tissue in pregnant women and the relationship between pregnant insulin resistance and gestational diabetes mellitus. Methods The expression of resistin protein in abdominal subcutaneous adipose tissue and placenta of pregnant and nonpregnant women was measured using western blot method. Results Resistin protein expression in placental tissue [(67 905±8441) A] was much higher than that in abdominal subcutaneous fat tissue in pregnant women [(40 718±3818)A](P<0.01)and nonpregnant women [(38 288±2084)A] (P<0.01) respectively, and there was no significant difference in abdominal subcutaneous fat tissue between pregnant and nonpregnant women. Conclusion Resistin is higher secreted from human placental tissue than fat, which is one of the factors leading to pregnant insulin resistance and gestational diabetes mellitus.
