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高同型半胱氨酸上调醛糖还原酶表达的病理生理意义 被引量：2

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摘要 高同型半胱氨酸(homocysteine，Hcy)是一个多种疾病发病的危险因子，其涉及的疾病谱较广，与心脑血管疾病、糖尿病、肾脏病、出生缺陷、老年病和一些精神疾病发病相关。醛糖还原酶(Aldose reductase，AR)是多元醇代谢途径(Polyol pathway)的反应限速酶，在高糖情况下，多元醇通路被激活，它是糖尿病慢性并发症发生、发展的重要原因之一。关于醛糖还原酶在糖尿病中的病理生理意义已有很多报道，但还未见高同型半胱氨酸和醛糖还原酶关系的报道。因此，本文初步探讨了高同型半胱氨酸上调醛糖还原酶表达的病理生理意义，可能对理解糖尿病并发症乃至临床诊断及治疗有潜在的指导意义。
作者 江河 王宪
机构地区 北京大学医学部生理学与病理生理学系
出处 《生理通讯》 2005年第3期65-68,共4页
关键词 高同型半胱氨酸 上调作用 醛糖还原酶 基因表达 病理生理意义 糖尿病慢性并发症 氧化应激 肺表面活性物质
分类号 R587.1 [医药卫生—内分泌] R363.1 [医药卫生—病理学]
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参考文献19

  • 1Moeckel G, Hallbach J, Guder WG. Purification of human and rat kidney aldose reductase. Enzyme Protein 1994-95 ; 48 : 45-50.
  • 2Chung S, La Mendola J. Cloning and sequence determ ination of human placental aldo se reductase gene. J Biol Chem 1989; 264:14775.
  • 3Lynch SM, Frei B. Mechanisms of copper2 and iron2 dependent oxidative modification of human low density lipoprotein [J]. Lipid Res 1993, 34:1 745- 1 753.
  • 4Srivastava S, Dixit BL, Ramana KV, Chandra A,Chandra D, Zacarias A, Petrash JM, Bhatnagar A,Srivastava SK. Structural and kinetic modifications ofaldose reductase by S-nitrosothiols. Biochem. J 2001,358, 111-118.
  • 5Holcomb GN. Klemm La, Dulin WE. The polyol pathway for glucose metabolism in tissues from normal, disbetic, and ketotic chinese hamsters Diabetologia 1974;10:549-53.
  • 6Cao D, Fan ST, Chung SS. Identification, and characterization of a novel human aldose reductase-like gene.J Biol Chem. 1998, 273:11429-35.
  • 7Yabe-Nishimura C. Aldose Reductase in Glucose Toxicity: A Potential Target for the Prevention of Diabetic Complications. Phannacol Rev 1998, 50: 21-33.
  • 8Dunlop M. Aldose reductase and the role of the polyol pathway in diabetic nephropathy. Kidney Int 2000,77:S3-12.
  • 9Raskin P. Risk factors for the development of complications of diabetic complications. J Diabetes Comp,1994; 8: 195.
  • 10Williamson JR, Chang K, Frangos M, et al. Hyperglycemic pseudohypoxia and diabetic complications.Diabetes 1993, 42:801 - 813.

二级参考文献22

  • 1Clarke R. Commentary:An updated review of the published studies of homocysteine and cardiovascular disease [J].Int J Epidemiol,2002,31 ( 1 ):70.
  • 2Graeme JH, John WE. Homocysteine and vascular disease[J].The Lancet, 1999,354:407～413.
  • 3Jacobsen DW, Gatautis VJ, Green R, et al. Rapid HPLCdetermination of total homocyteine and other thiols in serum and plasma:sex differences and correlation with cobalamia and folate concentration in healthy subjects[J].Clin Chem, 1994,40:873～881.
  • 4Nehler MR, Taylor LM, Porter JM. Homocysteine as a risk factor for atherosclerosis:A Review[J].Cardiovasc Pathol,1997,6:1～9.
  • 5Cattaneo M. Hyperhomocysteinemia, atheroscleros and thrombosis [J].Thromb Haemost, 1999,81:165～ 176.
  • 6Boysen G, Brander T, Christensen H, et al. Homocysteine and risk of recurrent stroke[J].Stroke,2003,34(5):1258～1261.
  • 7Martinelli I, Battaglioli T, Pedotti P, et al. Hperhomocysteine in cerebral vein thrombosis[J].Blood,2003,102(4):1363～1366.
  • 8Ducloux D,Motte G, Challier B, et al. Serum total homocysteine and cardiovascular Disease occurrence in chronic,stable renal transplant recipients:a prospective Study[J].J Am Soc Nephrol,2000,11:134～137.
  • 9Spark JI, Laws P, Fitridge R. The incidence of hyperhomocysteinemia in vascular Patients [J].Eur J Vasc Endovasc Surg,2003,26(5):558～561.
  • 10Blondel J, Glacet-Bernard A, Bayani N, et al. Retinal vein occlusion and hyperhomocysteine-mia [J].J Fr Ophtalmol,2003,26(3):249～253.

共引文献4

同被引文献16

  • 1Yushan HUANG~1,Kejun PENG~2,Juan SU~1,Yuping HUANG~3,Yizhon XU~1,and Shuren WANG~1 ~1Department of Pathophysiology,West China School of Preclinic Medical Sciences & Forensic Medicine,Sichuan University,Chengdu 610041.China,~2Department of Laboratory Medicine,Chengdu Medical College,Chengdu 610500,China,~3Department of Biochemistry and Molecular Bilogy,Gannan Medical College,Ganzhou 341000,China.Different Effects of Homocysteine and Oxidized Low Density Lipoprotein on Methylation Status in the Promoter Region of the Estrogen Receptor α Gene[J].Acta Biochimica et Biophysica Sinica,2007,39(1):19-26. 被引量：25
  • 2姜怡邓,张建中,黄英,苏娟,张敬各,王丽珍,韩晓群,王树人.高半胱氨酸在平滑肌细胞中介导DNA甲基化及机制的研究(英文)[J].生物化学与生物物理进展,2007,34(5):479-489. 被引量：11
  • 3Refsum H, Ueland P M, Nygard O, et al. Homocysteine and cardiovascular disease [ J ]. Annu Re-v Med, 1998, 49(1) : 31.
  • 4Thannickal V J, Fanburg B L. Reactiveoxygen speciesin cell signaling [ J ]. Am J Physiol: Lung Cell Mol Physiol, 2000, 279(6) : L1005.
  • 5Wang Z, Castresana M R, Newman W H. NF-kappa B is required for TNF-alpha-directed smooth muscle cell migration[J]. FEBS Lett, 2001, 508(3): 360.
  • 6Aerbajinai W, Zhu J, Gao Z, et al. Thalidomide induces gamma globulin gene expression through increased reactive oxygen species-mediated p38 MAPK signaling and histone H4 acetylat ion in adult erythropoiesis [ J ]. Blood, 2007, 110 (8) : 2864.
  • 7Hsu W H, Hsieh Y S, Kuo HC, et al. Berberine induces apoptosis in SW 620 human colonic carcinoma cells through generation of reactive oxygen species and activation of JNK/p38 MA-PK and FasL [ J ]. Arch Toxicol, 2007, 81(10): 719.
  • 8Kang K A, Lee K H, Zhang R, et al. Protective effect s of Castanopsis cuspidate through act-ivation of ERK and NF-kappa B on oxidative cell death induced by hydrogen peroxide[ J]. Toxicol Environ Health A, 2007, 70( 15/ 16) : 1319.
  • 9Miller F J, Filali M, Huss G J, et al. Cytokine activation of nuclear factor kappa B in vascular smooth muscle cells requires signaling endosomes containing Noxl and CIC-3[J]. Circ Res,2007, 101(7): 663.
  • 10ZHANG Jing-ge,LIU Jun-xu,LI Zhu-hua,WANG Li-zhen,JIANG Yi-deng,WANG Shu-ren.Dysfunction of endothelial NO system originated from homocysteine-induced aberrant methylation pattern in promoter region of DDAH2 gene[J].Chinese Medical Journal,2007(23):2132-2137. 被引量：15

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二级引证文献13

生理通讯
2005年 第3期

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