IgM-神经节苷脂GM_1抗体在运动神经元病中的初步观察

Observation of Antiganglioside GMl Antibody in Motor Neuron Disease

26例运动神经无病(MND)患者血清中IgM-神经节苷脂GM_1抗体检测的阳性率为65％,明显高于其他神经疾病(OND)组11％及正常人(NC)组。抗体效价在MND组为289.20±183.66,明显高于OND组(97.50±60)及NC组(<50),抗体效价>350时,仅见于MND组,各类MND的GM_1抗体阳性数及效价以下运动神经元病(LMND)最高,肌萎缩侧束硬化(ALS)次之,上运动神经元病(UMND)最低,GM_1抗体效价与病情相关(P<0.01),病情重、效价高。

The serum anti-GM1 antibody was measured using ELISA in 26 patients with motor neuron disease (MND), 18 cases of other nervous system diseases (OND) and 7 normal controls (NO. The result showed that 65. 38% in the MND cases were positive, while only 11% in the OND group, All of NC group were negative. There was statistically significant difference for the positive- rate between MND and OND (P<0. 01). The average antibody liter was 289. 20, 183. 66 in MND, 97. 50,60. 11 in OND and less than 50 in the NC. There was statistically significant difference in the average liter between MND and OND (P<0. 001). Over 350 antibody titer can only be found in the MND, less 350 titer in the OND, less than 50 in the NC. Those with high antibody liters (> 700) were predominantly distributed in patients with lower motor neuron disease and Amyotrophic lateral sclerosis. The degree of the antibody titers of all cases was correlated with the severity of the disease (P<0. 01).