摘要
本文报告112例血管母细胞瘤的临床、光镜和电镜观察结果。96.4%病例肿瘤位于后颅凹,临床症状以颅压增高和共济失调为主,伴有红细胞增多(18%)、白细胞增多(18.5%)及两者均增多(12.4%)。95例肿瘤肉眼发现为囊性,17例为实质性,光镜下几乎全有囊变。因此,囊变为此肿瘤的基本特征之一。光镜下瘤组织富于血窦,其间充满多角形的间质细胞,具有异形胞核和泡沫状的胞浆。电镜下有多数血管内皮和外皮细胞,以及富含溶酶体和脂滴的间质细胞。
112 cases of hemangioblastomas having the clinical light-electron microscopical features were reported. 96.4% of tumors located in the posterior fosa, including 88-8% in cerebellum. The majority of clinical symptoms were the increased intracranial pressures and ataxia, accompanied with increasing of red blood cells (18%) , of white blood cells (18.5%) and of both (12. 4%). 95 cases of tumors were cystic and 17 cases were solid macroscopically. The cystic changes were found almost in all cases microscopically. Therefore,the cyst change was one of the fundamentory evidences. The tumor tissues contained various vascular sinus between them presented polygonal stroma cells having plomorphic nuclei and foamy cytoplasm. In electron microscopy, there were numerous vascular endothelial and perithelial cells, and stroma cells containing many lysozames and fat drops. The relationships of tumor location and clinical manifestation, cyst formation, increasing of blood cells and tumor developing were discussed.
出处
《临床神经科学》
1994年第2期86-90,共5页
Chinese Journal of Clinical Neurosciences