摘要
本文采用大鼠全脑缺血模型,观测脑缺血再灌流脑组织Ca^(2+)依赖性中性蛋白酶(calci-um-activated neutral proteinase,calpain)活性的变化及海马C_(A1)区神经元损害改变。结果显示脑缺血再灌流脑组织calpain Ⅰ和calpain Ⅱ活性都明显升高(P<0.01),C_(A1)区神经元密度相应下降,提示calpains在脑缺血损害过程中可能起一定作用。
We have investigated the changes of calcium-activated neutral proteinases (calpains) activity during reperfusion after transient cerebral ischemia by using the four-vessel occlusion model of ischemia in rat. The results indicated that calpain I and calpain I activities increased significantly and neuronal density of the CAI region of the hippocampus decreased correspondently. It is concluded that calpains may be responsible for ischemic damage to the brain.
出处
《临床神经科学》
1994年第4期218-220,共3页
Chinese Journal of Clinical Neurosciences