免疫组织化学在鉴别非何杰金淋巴瘤与低分化和未分化癌中的应用

IMMUNOHISTOCHEMICAL METHOD FOR THE DIAGNOSIS BETWEEN NONHODKIN’S LYMPHOMAS AND POORLY DIFFERE-NTIATED OR UNDIFFERENTIATED CARCINOMAS

应用免疫组化ＡＢＣ法对１６５例非何杰金淋巴瘤（ＮＨＬ）与低分化和未分化癌进行了角蛋白（ｋｅ），上皮膜抗原（ＥＭＡ），癌胚抗原（ＣＥＡ）和白细胞共同抗原（ＬＣＡ）标记，１６５例标本中组织化学确诊为癌的有４１例，ＮＨＬ３４例，免疫组化结果与组织学诊断一致；ＮＨＬ与低分化和未分化癌需要鉴别的９０例，其中常规组织学未能确诊的有７２例，有争议的６例，这７８例标记后明确了诊断，另外１２例原组织学为误诊，已由免疫组化纠正。结果表明，应用免疫组化技术对ＮＨＬ与低分化和未分化癌的鉴别诊断有实用价值。

Immunohistochemical ABC method for Keratin proteins (ke), epith-elial mambrane antigen (EMA), Carcinoembryonic antigen(CEA) and leukocyte co-mmon antigen(LCA)has been used in paraffin sections of 165 cases in order to differ-entiate Non-Hodgkin’s lymphomas(NHl)with poorly differentiated or undifferentiatedcarcinomas. Among these cases, 4l cases of carcinomas and 34 cases of HNHL weredefinitely diangnosed by histopathology. The diagnostic results were the same as thosefrom immunothistochemistry. Among the rest 90 cases that need to be differentiate,there were 72 cases wihich were not definitely diagnosed with histopathology,another6 cases which still in controversy. However, these 78 cases were finally diagnosed bymarking method. The rest 12 cases misdiagnosed histologically had been corrected byimmunohistochemistry. Results showed that it is very helpful to use immunohisto-chemical technique for the differential diagnosis between NHL and poorly differentiatedor undifferentiated carcinomas, and this method has good practical value.