大鼠病理性微小血管吻合的研究

Study of pathological(atherosclerosis) microvascular anastomosis in rats

为探讨病理性微小血管吻合的可行性，用大鼠复制了与人类动脉粥样硬化相似的Ｍ ｎｃｈｅｒｂｅｒｇ型模型，进行了１０６例直径０．４～１．２ｍｍ的病理性微小血管吻合。术后２～３５ｄ，总通畅率９１％。其修复过程经组织学检查与对照及文献记载的正常血管吻合相比，结果无显著差异。提示吻合操作对病理血管只产生单一刺激，粥样硬化血管的病理状态不至于影响吻合血管修复。

In order to gain the experience in pathological microvascular anastomsis, Moncheberg's atherosclerosis(AS) models of rats, quite similar to the human's, were replicated and 106 anastomosis were performed on the AS vessels (diameters form 0.4 to 1.2 mm) with a patency rate of 91%2～35 days after the operation. Histological examination revealed no definite evidence of deteriorated repairing outcome by the morbid state of the AS vessels.It suggested that anastomotic event might only exert a single stimulation on the AS vessels. The pathologic state and course of the AS vessels showed neither aggravated by the injury response nordeteriorating the repairing outcome of anastomotic stoma after anastomosis. Satisfactory patency rate of the AS microvascular anastomosis can be achieved with the further perfection of microsurgical technique and preoperative management.